Antivirals against DNA viruses (hepatitis B and the herpes viruses)

Antiviral drugs against DNA viruses are widely used for the management of diseases caused by infections with the Herpes viruses and have recently been introduced for Hepatitis B. There are also several emerging treatments (i.e. those that are in clinical development) and novel treatments that are st...

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Bibliographic Details
Published in:Current opinion in pharmacology 2004-10, Vol.4 (5), p.453-464
Main Authors: Hewlett, Guy, Hallenberger, Sabine, Rübsamen-Waigmann, Helga
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - therapeutic use
Clinical Trials as Topic
Cytomegalovirus Infections - drug therapy
Hepatitis B - drug therapy
Hepatitis B virus
Herpes Simplex - drug therapy
Herpes Zoster - drug therapy
Herpesviridae Infections - drug therapy
Herpesvirus
Humans
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Summary:Antiviral drugs against DNA viruses are widely used for the management of diseases caused by infections with the Herpes viruses and have recently been introduced for Hepatitis B. There are also several emerging treatments (i.e. those that are in clinical development) and novel treatments that are still in the preclinical phase. Although the majority of emerging drugs are nucleoside analogues, there is a trend towards the development of non-nucleosidic drugs with unique mechanisms of action, in the hope that efficacy will be maximised and drug resistance and viral rebound minimised.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2004.06.004