Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris

Previous investigation has shown that Thymus Vulgaris (TV) modulates pain. The aim of this work was to examine the role of TV on acute and chronic pain and compares its effect with dexamethasone (DEX) and stress (ST) by using hot plate, tail flick and formalin tests in mice. In this study male albin...

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Published in:Pakistan journal of pharmaceutical sciences 2009-01, Vol.22 (1), p.83-89
Main Authors: Taherian, Abbas Ali, Babaei, Mahdi, Vafaei, Abbas Ali, Jarrahi, Morteza, Jadidi, Majid, Sadeghi, Hassan
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Chemical properties
Dexamethasone - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Formaldehyde
Health aspects
Hot Temperature
Male
Medicinal plants
Mice
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Nociception
Pain - etiology
Pain - prevention & control
Pain - psychology
Pain Measurement
Plant Extracts - pharmacology
Stress, Psychological
Thymes
Thymus Plant
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Summary:Previous investigation has shown that Thymus Vulgaris (TV) modulates pain. The aim of this work was to examine the role of TV on acute and chronic pain and compares its effect with dexamethasone (DEX) and stress (ST) by using hot plate, tail flick and formalin tests in mice. In this study male albino mice (25-30 g.) in 21 groups (n=147) were used. TV (100, 500 and 1000 mg/kg), DEX (0.5, 1 and 2 mg/kg) and vehicle (VEH) were injected 30 minutes before pain assessment tests. Stress was applied by 1 min swimming in cold water (18-22 degrees ). Acute and chronic pain was assessed by hot plate, tail flick and formalin tests. For assessment of the role of opioid receptors in antinoceception of TV extract, Naloxon (NAL, 2mg/kg, ip) as opioid receptor antagonist was injected before the injection of the more effective dose (500 mg/kg) of TV extract. Results indicated that TV, DEX and ST have analgesic effects in all tests (P
ISSN:1011-601X