Chitosan/nanohydroxyapatite composite membranes via dynamic filtration for guided bone regeneration

Chitosan/hydroxyapatite (HA) composite membranes were prepared by the coprecipitation method and a subsequent dynamic filtration and freeze‐drying process. The influences of the HA content of the membranes on their phase and morphology, mechanical properties, and bioactivity were investigated. FTIR...

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Bibliographic Details
Published in:Journal of Biomedical Materials Research Part B 2009-03, Vol.88A (3), p.569-580
Main Authors: Teng, Shu-Hua, Lee, Eun-Jung, Yoon, Byung-Ho, Shin, Du-Sik, Kim, Hyoun-Ee, Oh, Joong-Soo
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - metabolism
Animals
Bone Regeneration
Cell Line
chitosan
Chitosan - chemistry
composite membrane
Durapatite - chemistry
Filtration
guided bone regeneration
hydroxyapatite
Mice
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanostructures - chemistry
Nanostructures - ultrastructure
Spectrophotometry, Infrared
Stress, Mechanical
Tensile Strength
X-Ray Diffraction
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Summary:Chitosan/hydroxyapatite (HA) composite membranes were prepared by the coprecipitation method and a subsequent dynamic filtration and freeze‐drying process. The influences of the HA content of the membranes on their phase and morphology, mechanical properties, and bioactivity were investigated. FTIR analysis revealed that chitosan and HA had good miscibility over a wide range of compositions. Needle‐like HA nanocrystals with low crystallinity were uniformly embedded in the chitosan matrix. As the HA content was increased, the tensile strength of the membranes exhibited a steady decrease, while the elastic modulus increased by a factor of 2 when 20% HA was added. The results of the in vitro cell culture showed that the highest alkaline phosphatase level was achieved when 30% HA was contained in the composites. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
ISSN:1549-3296
1552-4965
1552-4981
DOI:10.1002/jbm.a.31897