Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation

Previous published work with the novel anticonvulsant, analgesic and anti-anxiety medication, pregabalin (Lyrica ®), has shown that it has anxiolytic-like actions in several animal behavioral models. However, pregabalin is structurally and pharmacologically different from other classes of known anxi...

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Bibliographic Details
Published in:Neuropharmacology 2009-02, Vol.56 (2), p.379-385
Main Authors: Siok, Chester J., Taylor, Charles P., Hajós, Mihály
Format: Article
Language:English
Subjects:
Afferent Pathways - physiology
Alpha 2_delta
Animals
Anticonvulsants - pharmacology
Anxiety
Biophysics
Brain Stem - physiology
Diazepam
Diazepam - pharmacology
Dose-Response Relationship, Drug
EEG
Electric Stimulation - methods
GABA A
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
Hippocalcin - drug effects
Hippocalcin - physiology
Hippocampus
Male
Pregabalin
Rats
Rats, Sprague-Dawley
Spectrum Analysis
Theta
Theta Rhythm - drug effects
Time Factors
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Summary:Previous published work with the novel anticonvulsant, analgesic and anti-anxiety medication, pregabalin (Lyrica ®), has shown that it has anxiolytic-like actions in several animal behavioral models. However, pregabalin is structurally and pharmacologically different from other classes of known anxiolytic drugs, and the mechanisms that alter brain activity to produce anxiolytic-like actions are not well understood. In an effort to determine more about the cellular mechanisms of pregabalin, we studied its effects on hippocampal theta activity of urethane-anesthetized rats that was elicited by electrical stimulation of the nucleus pontis oralis (nPO) in the brainstem. We found that systemic administration of pregabalin significantly reduced the frequency of stimulation-induced hippocampal theta activity similarly to the effects of diazepam. In addition, pregabalin (but not diazepam) significantly altered the stimulus intensity/frequency relationship, and increased slow delta oscillation (
ISSN:0028-3908
1873-7064
DOI:10.1016/j.neuropharm.2008.09.013