Cell survival and chromosomal aberrations in CHO-K1 cells irradiated by carbon ions

Chinese hamster ovary CHO-K1 cells were exposed to high LET 12C-beam (LET: 830 keV/μm) in the dose range of 0–6 Gy and to 60Co irradiation and the RBE value was obtained. Effects of 12C-beam exposure on cell survival and chromosomal aberrations were calculated. The chromosomal aberration data were f...

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-03, Vol.67 (3), p.447-453
Main Authors: Czub, J., Banaś, D., Błaszczyk, A., Braziewicz, J., Buraczewska, I., Choiński, J., Górak, U., Jaskóła, M., Korman, A., Lankoff, A., Lisowska, H., Łukaszek, A., Szefliński, Z., Wójcik, A.
Format: Article
Language:English
Subjects:
12C-beam
Animals
Carbon Radioisotopes
Cell survival
Cell Survival - radiation effects
CHO Cells - radiation effects
Chromosomal aberrations
Chromosome Aberrations - radiation effects
Cricetinae
Cricetulus
High LET radiation
Ions
Poisson Distribution
Radiation
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Summary:Chinese hamster ovary CHO-K1 cells were exposed to high LET 12C-beam (LET: 830 keV/μm) in the dose range of 0–6 Gy and to 60Co irradiation and the RBE value was obtained. Effects of 12C-beam exposure on cell survival and chromosomal aberrations were calculated. The chromosomal aberration data were fitted with linear equation. The distribution of aberration in cells was examined with a standard u-test and used to evaluate the data according to Poisson probabilities. The variance to the mean ratio σ 2/ Y and the dispersion index ( u) were determined. Overdispersion was significant ( p
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2008.06.016