Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin

Summary objective  Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (S...

Full description

Saved in:
Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2004-09, Vol.61 (3), p.339-346
Main Authors: López-Bermejo, Abel, Casano-Sancho, Paula, Fernández-Real, José Manuel, Kihara, Shinji, Funahashi, Tohru, Rodríguez-Hierro, Francisco, Ricart, Wifredo, Ibañez, Lourdes
Format: Article
Language:English
Subjects:
Adiponectin
Biological and medical sciences
Blood Glucose - analysis
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Endocrinopathies
Female
Fetal Growth Retardation - blood
Fundamental and applied biological sciences. Psychology
Growth
Homeostasis
Humans
Infant, Newborn
Infant, Small for Gestational Age
Insulin - blood
Insulin Resistance
Intercellular Signaling Peptides and Proteins - blood
Lipids - blood
Logistic Models
Male
Medical sciences
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary objective  Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). design  Cross‐sectional, hospital‐based study dealing with insulin sensitivity in SGA children. patients  Thirty‐two prepubertal children born SGA (age 5·4 ± 2·9 years) and 37 prepubertal children born appropriate for gestational age (AGA, age 5·9 ± 3·0 years). measurements  Serum levels of fasting glucose, serum lipids, insulin (immunometric assay) and adiponectin concentrations (ELISA) were assessed, and insulin resistance (IR) and insulin secretion (β‐cell) were calculated by the homeostasis model of assessment (HOMA). results  SGA children had similar HOMA‐IR, HOMA‐β‐cell and adiponectin concentrations than AGA children. However, in a separate analysis of subjects older than 3 years of age, SGA children showed higher HOMA‐IR after adjusting for sex, age and body mass index (BMI) standard deviation score (SDS). Circulating adiponectin was higher in SGA children [adjusted means: 14·5 mg/l (95% CI 12·9–16·1) and 18·7 mg/l (95% CI 17·0–20·3) for AGA and SGA children, respectively; P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2004.02102.x