Organocatalytic asymmetric alkylation of aldehydes by S(N)1-type reaction of alcohols

Work-alcoholic! The elusive enantioselective catalytic alpha-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA = trifluoroacetic acid).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2009, Vol.48 (7), p.1313-1316
Main Authors: Cozzi, Pier Giorgio, Benfatti, Fides, Zoli, Luca
Format: Article
Language:English
Online Access:Get full text
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Summary:Work-alcoholic! The elusive enantioselective catalytic alpha-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA = trifluoroacetic acid).
ISSN:1521-3773
DOI:10.1002/anie.200805423