Use of radioisotopic esophageal transit in the assessment of patients with symptoms of reflux and non-specific esophageal motor disorders

The purposes of this study were to assess the esophageal clearance of a radioisotopic bolus in patients with symptoms of reflux and evaluate the impact of manometric abnormalities on scintigraphic esophageal transit. Esophageal clearance was assessed in a supine position and indicated by the retaine...

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Bibliographic Details
Published in:Diseases of the esophagus 2004-01, Vol.17 (3), p.218-222
Main Authors: Iascone, C., Di Giulio, E., Maffi, C., Ruperto, M.
Format: Article
Language:English
Subjects:
Administration, Oral
Case-Control Studies
Endoscopy, Gastrointestinal
esophageal clearance
esophageal motility disorders
Esophageal Motility Disorders - diagnostic imaging
Esophageal Motility Disorders - physiopathology
Esophagus - diagnostic imaging
Esophagus - physiopathology
Gastrointestinal Transit - physiology
Humans
Hydrogen-Ion Concentration
Manometry
Monitoring, Physiologic
radioisotopic esophageal transit
Radionuclide Imaging
Radiopharmaceuticals
Supine Position
Technetium Tc 99m Sulfur Colloid
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Summary:The purposes of this study were to assess the esophageal clearance of a radioisotopic bolus in patients with symptoms of reflux and evaluate the impact of manometric abnormalities on scintigraphic esophageal transit. Esophageal clearance was assessed in a supine position and indicated by the retained radioactivity in the esophagus at 10, 20, 30 and 40 s after the ingestion of a liquid bolus labeled with 2 mCi 99 mTc‐SC. The study included 214 consecutive patients with symptoms of reflux and 11 normal controls. The results were compared to the motility findings detected on manometry performed on a separate occasion. Esophageal manometry was normal in 93 patients. Nonspecific esophageal motor disorders were identified in 121 patients and were classified into: ‘predominantly nonpropagated activity’, ‘predominantly low‐amplitude peristaltic contractions’ and ‘miscellaneous disorders’ diagnosed in 27, 47 and 47 patients, respectively. The radionuclide clearance was significantly delayed in the overall group of patients compared with that of normal controls (P < 0.001); in patients with reflux symptoms and nonspecific esophageal motor disorders compared with patients with reflux symptoms and ‘normal manometry’ (P 
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2004.00411.x