Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants

In our joint project involving search of anti-tumor promoters from natural plant sources, six phenylpropanoids and seven phytoquinoids isolated from three Illicium plants (Illiciaceae) were tested for their inhibitory activities against Epstein–Barr virus early antigen (EBV-EA) activation induced by...

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Bibliographic Details
Published in:Cancer letters 2004-10, Vol.214 (2), p.165-169
Main Authors: Itoigawa, Masataka, Ito, Chihiro, Tokuda, Harukuni, Enjo, Fumio, Nishino, Hoyoku, Furukawa, Hiroshi
Format: Article
Language:English
Subjects:
Anti-tumor promoter
Antigens, Viral - analysis
Cancer
Cancer chemopreventive activity
Chemoprevention
Drug Screening Assays, Antitumor
Epstein-Barr virus
Epstein–Barr virus activation test
Humans
Hydroquinones - pharmacology
Illiciaceae
Illicium
Illicium - chemistry
Lymphoma - pathology
Medical research
Phenols
Phenylpropanoids
Phytoquinoids
Plant Extracts - pharmacology
Propanols - pharmacology
Rodents
Tumor Cells, Cultured
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Summary:In our joint project involving search of anti-tumor promoters from natural plant sources, six phenylpropanoids and seven phytoquinoids isolated from three Illicium plants (Illiciaceae) were tested for their inhibitory activities against Epstein–Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate in Raji cells. All tested compounds showed inhibitory activity against the EBV-EA activation even at 1×10 mol ratio, and the inhibitory activity of their compounds was found to be more than that of β-carotene. Two phenylpropanoids having prenyl group, 4-allyl-2-methoxy-6-(3-methyl-2-butenyl)phenol (3) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol (4), showed more potent activities as anti-tumor promoters (IC 50 224 and 217 mol ratio/TPA, respectively). The presence of a prenyl moiety in the phenylpropanoids plays an important role in anti-tumor promoting activity as xanthone, coumarin and flavonoid previously reported. This investigation indicated that prenylated phenylpropanoids might be valuable as potential cancer chemopreventive agents.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.05.005