Photocrosslinkable Chitosan Hydrogel Can Prevent Bone Formation in Both Rat Skull and Fibula Bone Defects

UV light irradiation to a photocrosslinkable chitosan (Az‐CH‐LA) resulted in an insoluble and flexible hydrogel within 30 s. The purpose of this study was to evaluate the ability of the photocrosslinkable chitosan to inhibit bone formation in the bone defects. A 5‐mm‐diameter defect was made in the...

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Bibliographic Details
Published in:Artificial organs 2009-01, Vol.33 (1), p.74-77
Main Authors: Tsuda, Yoshifumi, Ishihara, Masayuki, Amako, Masatoshi, Arino, Hiroshi, Hattori, Hidemi, Kanatani, Yasuhiro, Yura, Hirofumi, Nemoto, Koichi
Format: Article
Language:English
Subjects:
Animals
Bone formation
Chitosan - pharmacology
Chitosan - radiation effects
Fibula - drug effects
Hydrogel
Hydrogels - pharmacology
Hydrogels - radiation effects
Male
Osteogenesis - drug effects
Photocrosslinkable chitosan
Rats
Rats, Sprague-Dawley
Skull - drug effects
Synostosis
Tissue engineering
Ultraviolet Rays
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Summary:UV light irradiation to a photocrosslinkable chitosan (Az‐CH‐LA) resulted in an insoluble and flexible hydrogel within 30 s. The purpose of this study was to evaluate the ability of the photocrosslinkable chitosan to inhibit bone formation in the bone defects. A 5‐mm‐diameter defect was made in the rat calvarium, and then photocrosslinkable chitosan was implanted and irradiated with UV for 30 s. Furthermore, a 2‐mm defect was made in the fibula of a rat hind leg, and then photocrosslinkable chitosan was implanted and irradiated with UV. Bone formations in the rat skull and fibula defects with photocrosslinkable chitosan hydrogel were significantly prevented for 8 weeks. Thus, the chitosan hydrogel has an inhibitory effect on bone formation.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2008.00676.x