Carbamazepine enhances brain production of kynurenic acid in vitro

Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5–3 mM) enhanced kynurenic aci...

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Bibliographic Details
Published in:European journal of pharmacology 2004-09, Vol.498 (1), p.325-326
Main Authors: Kocki, Tomasz, Kocki, Janusz, Wielosz, Marian, Turski, Waldemar A., Urbanska, Ewa M.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Anticonvulsants - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Brain - metabolism
Carbamazepine
Carbamazepine - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - enzymology
Cerebral Cortex - metabolism
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
In Vitro Techniques
Isoenzymes - metabolism
Kynurenic acid
Kynurenic Acid - metabolism
Kynurenine - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Transaminases - metabolism
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Summary:Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5–3 mM) enhanced kynurenic acid synthesis in rat cortical slices and also increased the activity of kynurenine aminotransferase (KAT) I at 0.1–3.0 mM concentration. Thus, anticonvulsant drugs, such as carbamazepine, might act partially via stimulation of kynurenic acid production.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.07.088