Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modificat...

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Bibliographic Details
Published in:Modern pathology 2009-02, Vol.22 (2), p.252-260
Main Authors: Tzao, Ching, Tung, Ho-Jui, Jin, Jong-Shiaw, Sun, Guang-Huan, Hsu, Han-Shui, Chen, Ban-Hen, Yu, Cheng-Ping, Lee, Shih-Chun
Format: Article
Language:English
Subjects:
Acetylation
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Cell Differentiation
DNA methylation
Epigenetics
Esophageal cancer
Esophageal Neoplasms - chemistry
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagectomy
Female
Histones - analysis
Hospitals
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Laboratory Medicine
Lymphatic Metastasis
Lysine
Male
Medical prognosis
Medical records
Medicine
Medicine & Public Health
Methylation
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
original-article
Pathology
Patients
Protein Processing, Post-Translational
Retrospective Studies
Thoracic surgery
Time Factors
Treatment Outcome
Tumors
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Summary:Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modification as outcome predictor in patients undergoing esophagectomy for esophageal squamous cell carcinoma. A retrospective clinicopathologic analysis was undertaken of 97 patients with esophageal squamous cell carcinoma who recovered from esophagectomy. Immunohistochemical expression of five histone modification markers, acetylated histone 3 lysine 18 (H3K18Ac), acetylated histone 4 lysine 12 (H4K12Ac), dimethylated histone 4 arginine 3 (H4R3diMe), dimethylated histone 3 lysine 4 (H3 K4diMe), and trimethylated histone 3 lysine 27 (H3K27triMe) was assessed in paraffin-embedded tumor samples. Results were analyzed in relation to patients’ clinicopathologic parameters. There was a positive relationship between tumor differentiation and H3K18Ac ( P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2008.172