Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative

Beyond treating headaches: The derivatization of biologically active compounds by organometallic units modulates their pharmacological properties. In studies of antitumor‐related biochemical properties, the Co2(CO)6 derivative of aspirin 1 shows significantly modified influence on several relevant p...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (6), p.1160-1163
Main Authors: Ott, Ingo, Kircher, Brigitte, Bagowski, Christoph P, Vlecken, Danielle H.W, Ott, Elisabeth B, Will, Joanna, Bensdorf, Kerstin, Sheldrick, William S, Gust, Ronald
Format: Article
Language:English
Subjects:
angiogenesis
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - pharmacology
Animals
aspirin
Aspirin - chemistry
Aspirin - pharmacology
bioorganometallic chemistry
Caspase 3 - metabolism
cobalt
Cobalt - chemistry
cyclooxygenase
Cyclooxygenase 2 - metabolism
Cyclooxygenase 2 Inhibitors - chemistry
Cyclooxygenase 2 Inhibitors - pharmacology
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Protein Structure, Tertiary
Structure-Activity Relationship
Tandem Mass Spectrometry
Zebrafish
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Beyond treating headaches: The derivatization of biologically active compounds by organometallic units modulates their pharmacological properties. In studies of antitumor‐related biochemical properties, the Co2(CO)6 derivative of aspirin 1 shows significantly modified influence on several relevant pathways, which might be based on an altered interaction with the target enzyme COX‐2.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200803347