Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes

Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) can generate afterdepolarizations, and these have the potential to initiate arrhythmias. Therefore, an association may exist between spontaneous SR Ca2+ release and initiation of atrial fibrillation (AF), but this has not yet been reporte...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-09, Vol.110 (11), p.1358-1363
Main Authors: Hove-Madsen, Leif, Llach, Anna, Bayes-Genís, Antoni, Roura, Santiago, Rodriguez Font, Enrique, Arís, Alejandro, Cinca, Juan
Format: Article
Language:English
Subjects:
Aged
Atrial Appendage - physiopathology
Atrial Appendage - ultrastructure
Atrial Fibrillation - physiopathology
Calcium Signaling - physiology
Female
Heart Atria - physiopathology
Heart Atria - ultrastructure
Humans
Male
Microscopy, Confocal
Middle Aged
Myocytes, Cardiac - physiology
Myocytes, Cardiac - ultrastructure
Patch-Clamp Techniques
Sarcoplasmic Reticulum - secretion
Sodium-Calcium Exchanger - metabolism
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Summary:Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) can generate afterdepolarizations, and these have the potential to initiate arrhythmias. Therefore, an association may exist between spontaneous SR Ca2+ release and initiation of atrial fibrillation (AF), but this has not yet been reported. Spontaneous Ca2+ release from the SR, manifested as Ca2+ sparks and Ca2+ waves, was recorded with confocal microscopy in atrial myocytes isolated from patients with and those without AF. In addition, the spontaneous inward current associated with Ca2+ waves was measured with the use of the perforated patch-clamp technique. The Ca2+ spark frequency was higher in 8 patients with AF than in 16 patients without (6.0+/-1.2 versus 2.8+/-0.8 sparks/mm per second, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000141296.59876.87