Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis

• Published in: Journal of the American College of Cardiology 2004-09, Vol.44 (6), p.1292-1297
• Main Authors: Nishii, Mototsugu, Inomata, Takayuki, Takehana, Hitoshi, Takeuchi, Ichiro, Nakano, Hironari, Koitabashi, Toshimi, Nakahata, Jun-ichi, Aoyama, Naoyoshi, Izumi, Tohru
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - blood; Cardiology; Cardiology. Vascular system; Enzymes; Female; Heart; Heart attacks; Heart rate; Humans; Interferon-gamma - blood; Interleukin-10 - blood; Japan; Male; Medical prognosis; Medical sciences; Middle Aged; Mortality; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - mortality; Myocarditis - blood; Myocarditis - diagnosis; Myocarditis - mortality; Myocarditis. Cardiomyopathies; Natriuretic Peptide, Brain - blood; Patient Admission; Predictive Value of Tests; Prognosis; Severity of Illness Index; Survival Analysis; Treatment Outcome; Troponin T - blood; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2004.01.055

We assessed the significance of serum cytokine levels in patients with fulminant myocarditis. Although many investigations have demonstrated the crucial role of cytokines in the development of myocarditis, it remains uncertain whether serum levels of cytokines enable one to predict the prognosis of human myocarditis, especially concerning cardiogenic shock (CS) requiring a mechanical cardiopulmonary support system (MCSS). We studied 22 consecutive patients with fulminant myocarditis and compared them with 15 patients with acute myocardial infarction (AMI) requiring MCSS. The patients with myocarditis were classified into three groups: eight patients with CS requiring MCSS on admission (group 1); six patients who unexpectedly lapsed into CS requiring MCSS more than two days after catecholamine had been initiated (group 2); and eight patients without MCSS (group 3). Furthermore, 14 patients with myocarditis requiring MCSS were divided into a fatal group (n = 5) and a survival group (n = 9). Biochemical markers, including serum cytokine levels and hemodynamic variables on admission, were analyzed. Serum levels of interleukin (IL)-10 and tumor necrosis factor-alpha, but not other cytokines, were significantly higher in myocarditis than in AMI. Only serum levels of IL-10 were significantly higher in group 1 and 2 than in group 3 (49.1 ± 37.5/20.7 ± 17.6 pg/ml vs. 2.4 ± 1.1 pg/ml; p = 0.0008/0.0012). Serum IL-10 levels were also significantly higher in the fatal group than in the survival group with myocarditis (74.0 ± 27.0 pg/ml vs. 16.4 ± 8.8 pg/ml; p = 0.003). Serum IL-10 levels on admission enabled one to predict subsequent CS requiring MCSS and mortality of fulminant myocarditis patients.