Delayed exercise-induced protection against arrhythmias in dogs—effect of celecoxib

A 20-min period of treadmill exercise in dogs, sufficient to increase heart rate by 90–100 beats min −1, markedly decreases the severity of the life-threatening ventricular arrhythmias that result when, following anaesthesia 24 h later, the left coronary artery is occluded. This protection was unaff...

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Bibliographic Details
Published in:European journal of pharmacology 2004-09, Vol.499 (1), p.197-199
Main Authors: Nagy, Orsolya, Hajnal, Ágnes, Parratt, James R., Végh, Ágnes
Format: Article
Language:English
Subjects:
Animals
Arrhythmias
Arrhythmias, Cardiac - physiopathology
Arrhythmias, Cardiac - prevention & control
Biological and medical sciences
Celecoxib
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors - pharmacology
Delayed preconditioning
Dogs
Heart Rate - drug effects
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Isoenzymes - antagonists & inhibitors
Medical sciences
Pharmacology. Drug treatments
Physical Conditioning, Animal - physiology
Prostaglandin-Endoperoxide Synthases
Pyrazoles - pharmacology
Sulfonamides - pharmacology
Time Factors
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Summary:A 20-min period of treadmill exercise in dogs, sufficient to increase heart rate by 90–100 beats min −1, markedly decreases the severity of the life-threatening ventricular arrhythmias that result when, following anaesthesia 24 h later, the left coronary artery is occluded. This protection was unaffected by the administration of the selective cyclooxygenase-2 inhibitor celecoxib (two times 3 mg kg −1 given intravenously). These results show that prostacyclin, derived from cyclooxygenase-2, plays no role in this pronounced delayed cardioprotection.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.07.068