Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention

Activin A, a member of the transforming growth factor-β cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI). The subjects...

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Bibliographic Details
Published in:Clinica chimica acta 2009-03, Vol.401 (1), p.3-7
Main Authors: Miyoshi, Toru, Hirohata, Satoshi, Uesugi, Tadahisa, Hirota, Minoru, Ohnishi, Hiromichi, Nogami, Kunio, Hatanaka, Kunihiko, Ogawa, Hiroko, Usui, Shinichi, Kusachi, Shozo
Format: Article
Language:English
Subjects:
Activins - blood
Aged
Angina Pectoris - diagnosis
Angioplasty, Balloon, Coronary
Coronary artery disease
Creatine Kinase - blood
Creatine Kinase, MB Form - blood
Diagnosis
Female
Humans
Immunoassay
Inflammation
Male
Middle Aged
Myocardial Infarction - diagnosis
Myocardial Infarction - pathology
Myocardial Infarction - surgery
Regression Analysis
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Summary:Activin A, a member of the transforming growth factor-β cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI). The subjects were 30 AMI patients, 20 stable angina pectoris (AP) patients and 20 normal subjects. The serum levels of activin A in AMI patients were measured before PCI and on days 1, 2, 7, and 14. Activin A levels before PCI in AMI patients (557 ± 255 pg/ml) showed a significantly higher value than those in AP patients (364 ± 159 pg/ml) and control subjects (316 ± 144 pg/ml). Increased serum activin A level before PCI was decreased on day 2, and then gradually re-elevated on days 7 and 14. The serum activin A level before PCI was correlated with log-transformed peak creatine kinase (CK) as a surrogate of infarct size ( r = 0.48, p = 0.008). Stepwise multiple regression analysis demonstrated that the serum activin A level before PCI was an independent predictor of peak CK. The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2008.10.027