Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats

Purpose The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model. Methods Forty Wistar albino rats were grou...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2009-02, Vol.13 (2), p.282-286
Main Authors: Ersoy, Eren, Ozturk, Vedat, Yazgan, Aylin, Ozdogan, Mehmet, Gundogdu, Haldun
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Wall - pathology
Abdominal Wall - surgery
Animals
Biocompatible Materials - therapeutic use
Biodegradable materials
Female
Gastroenterology
Hyaluronic Acid - therapeutic use
Lactic Acid - therapeutic use
Laparotomy - adverse effects
Medicine
Medicine & Public Health
Membranes, Artificial
Original Article
Plastics
Polyesters
Polylactic acid
Polymers
Polymers - therapeutic use
Rats
Rats, Wistar
Surgery
Tissue Adhesions - etiology
Tissue Adhesions - prevention & control
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Summary:Purpose The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model. Methods Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate–carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems. Results When compared to control group, polylactic acid group showed significantly less inflammation and adhesion ( p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-008-0678-5