Endometrial polyps and associated factors in Danish women aged 36-74 years

Objective To identify factors associated with endometrial polyps. Study Design Case-control study of 140 women with endometrial polyps and 367 controls. Information on potentially associated factors was obtained by a validated questionnaire. Results In an age-adjusted logistic regression model, the...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2009-02, Vol.200 (2), p.147.e1-147.e6
Main Authors: Dreisler, Eva, MD, Sorensen, Soren Stampe, MD, DMSc, Lose, Gunnar, MD, DMSc
Format: Article
Language:English
Subjects:
Adult
Age Factors
associated factors
Biological and medical sciences
Case-Control Studies
Denmark
Endometrial Neoplasms - epidemiology
endometrial polyps
Female
Gynecology. Andrology. Obstetrics
Humans
Logistic Models
Medical sciences
Menopause
Middle Aged
Obstetrics and Gynecology
Polyps
Prospective Studies
uterine polyps
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Summary:Objective To identify factors associated with endometrial polyps. Study Design Case-control study of 140 women with endometrial polyps and 367 controls. Information on potentially associated factors was obtained by a validated questionnaire. Results In an age-adjusted logistic regression model, the following was positively associated with endometrial polyps: current use of hormone therapy (odds ratio, 2.81; 95% CI, 1.29-6.13) and being overweight (body mass index > 25 kg/m2 ) (odds ratio, 2.06; 95% CI, 1.12-3.79) (postmenopausal women). Negatively associated was use of oral contraceptive pills (odds ratio, 0.20; 95% CI, 0.06-0.66). Histopathology diagnosed benign endometrial polyps (n = 137), polyp with premalignant disease (n = 3), and benign polyp with concomitant complex hyperplasia/endometrial cancer (n = 3). Conclusion Being overweight and current use of hormone therapy in postmenopausal women were positively associated, whereas the use of oral contraceptive pills was negatively associated with endrometrial polyps. Hypertension and cervical polyps were not associated with endometrial polyps. Endometrial polyps were infrequently related to premalignant and malignant disease.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2008.08.065