The effect of carbenoxolone on hippocampal formation theta rhythm in rats: In vitro and in vivo approaches

Abstract The role of gap junction (GJ) coupling in the generation of hippocampal formation theta rhythm was investigated in vitro , with use of brain slices, and in vivo , with use of urethane anesthetized rats. Carbenoxolone, the succinyl ester of glycyrrhetinic acid, and GJ blocker reversibly abol...

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Bibliographic Details
Published in:Brain research bulletin 2009-03, Vol.78 (6), p.290-298
Main Authors: Bocian, Renata, Posłuszny, Anna, Kowalczyk, Tomasz, Gołębiewski, Henryk, Konopacki, Jan
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Carbachol - pharmacology
Carbenoxolone - pharmacology
Gap junctions
Gap Junctions - drug effects
Hippocampal oscillations
Hippocampus - drug effects
In Vitro Techniques
Male
Neurology
Patch-Clamp Techniques
Rat
Rats
Rats, Wistar
Theta Rhythm - drug effects
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Summary:Abstract The role of gap junction (GJ) coupling in the generation of hippocampal formation theta rhythm was investigated in vitro , with use of brain slices, and in vivo , with use of urethane anesthetized rats. Carbenoxolone, the succinyl ester of glycyrrhetinic acid, and GJ blocker reversibly abolished hippocampal formation theta rhythm recorded in slice preparations and urethane anesthetized rats. The present study yielded novel data which demonstrated that the pattern of delay in blockage of theta rhythm after carbenoxolone treatment, and the pattern of theta recovery after administration of this agent, require a specific time period (2–3 h for delay and 8–12 h for recovery), one that can be demonstrated using different experimental protocols.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2008.10.005