Evaluation of left ventricular short- and long-axis function in severe mitral regurgitation using 2-dimensional strain echocardiography

Background Few data exist on the changes in left ventricular (LV) short- and long-axis function and their usefulness as markers of LV contractile function in patients with chronic, severe mitral regurgitation (MR). Methods We studied 59 patients who had severe MR with an ejection fraction ≥50% and 3...

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Published in:The American heart journal 2009-02, Vol.157 (2), p.345-351
Main Authors: Kim, Min-Seok, MD, Kim, Yong-Jin, MD, Kim, Hyung-Kwan, MD, Han, Joo-Yong, MD, Chun, Hong-Gu, PhD, Kim, Hee-Chan, MD, Sohn, Dae-Won, MD, Oh, Byung-Hee, MD, Park, Young-Bae, MD
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Biological and medical sciences
Cardiac arrhythmia
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular system
Chronic Disease
Echocardiography
Echocardiography, Doppler
Endocardial and cardiac valvular diseases
Female
Flow velocity
Heart
Heart attacks
Heart rate
Humans
Intubation
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Mitral Valve Insufficiency - diagnostic imaging
Mitral Valve Insufficiency - physiopathology
Stroke
Surgery
Ultrasonic investigative techniques
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left - physiology
Young Adult
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Summary:Background Few data exist on the changes in left ventricular (LV) short- and long-axis function and their usefulness as markers of LV contractile function in patients with chronic, severe mitral regurgitation (MR). Methods We studied 59 patients who had severe MR with an ejection fraction ≥50% and 34 healthy controls. Speckle tracking imaging was performed to measure peak systolic radial (SRR ), circumferential (SRC ), and longitudinal strain rates (SRL ). In all patients, the peak rate of LV pressure rise (peak dP/dt) was measured using a micromanometer-tipped catheter. The patients were subdivided into patients with preserved (group 1, peak dP/dt ≥1,300 mm Hg/s [n = 30]) and depressed (group 2 [n = 29]) contractile function. Results SRL was significantly depressed in groups 1 and 2 when compared with the control group, but there was no difference between groups 1 and 2. In contrast, SRR and SRC were depressed only in group 2, whereas there were no differences between the control group and group 1. SRR and SRC correlated well with peak dP/dt ( r = 0.71, P
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2008.10.004