Allosterically Driven Multicomponent Assembly

Bound to cooperate: Binding of dimethylviologen in the cavity of a Zn porphyrin host dramatically increases the affinity of the host for N‐donating ligands and vice versa (see scheme). These positive heterotropic allosteric effects are exploited to direct complex equilibrium mixtures towards a singl...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-09, Vol.43 (36), p.4755-4759
Main Authors: Thordarson, Pall, Coumans, Ruud G. E., Elemans, Johannes A. A. W., Thomassen, Paul J., Visser, Johan, Rowan, Alan E., Nolte, Roeland J. M.
Format: Article
Language:English
Subjects:
allosterism
cooperative phenomena
Ligands
Models, Chemical
Models, Molecular
Molecular Conformation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
porphyrins
self-assembly
supramolecular chemistry
Zinc - chemistry
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Summary:Bound to cooperate: Binding of dimethylviologen in the cavity of a Zn porphyrin host dramatically increases the affinity of the host for N‐donating ligands and vice versa (see scheme). These positive heterotropic allosteric effects are exploited to direct complex equilibrium mixtures towards a single self‐assembled species. This allosteric magnification was used to obtain a pentameric sandwich architecture from a complex mixture of components.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460398