Can we really learn from model pathogens?

Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly...

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Bibliographic Details
Published in:Trends in immunology 2004-10, Vol.25 (10), p.524-528
Main Authors: Müllbacher, Arno, Regner, Matthias, Wang, Yang, Lee, Eva, Lobigs, Mario, Simon, Markus
Format: Article
Language:English
Subjects:
Animals
Cytotoxicity, Immunologic
Disease Models, Animal
Flaviviridae Infections - immunology
Flavivirus - immunology
Host-Parasite Interactions - immunology
Mice
Models, Immunological
Orthopoxvirus - immunology
Poxviridae Infections - immunology
Signal Transduction - immunology
T-Lymphocytes, Cytotoxic - immunology
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Summary:Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly or indirectly exert antiviral activity. Mice respond to infection by closely related viruses with a vigorous Tc response, which is characterized by extensive crossreactivity on target cells infected with these viruses. However, the action of these cells can be beneficial, detrimental or neutral. From our current state of knowledge, no generalizations as to protective or detrimental effects of cytolytic effector functions in recovery from virus infections can be made. Thus, virus–host immune interactions have to be assessed individually and cannot be generalized.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2004.08.004