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Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies
Objective To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non‐diabetic mothers. Methods Fetal echocardiography was performed in women with pre‐exi...
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| Published in: | Ultrasound in obstetrics & gynecology 2009-02, Vol.33 (2), p.182-187 |
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| container_end_page | 187 |
| container_issue | 2 |
| container_start_page | 182 |
| container_title | Ultrasound in obstetrics & gynecology |
| container_volume | 33 |
| creator | Zielinsky, P. Luchese, S. Manica, J. L. Piccoli, A. L. Nicoloso, L. H. Leite, M. F. Hagemann, L. Busato, A. Moraes, M. R. |
| description | Objective
To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non‐diabetic mothers.
Methods
Fetal echocardiography was performed in women with pre‐existing or gestational diabetes and in non‐diabetic controls between 25 weeks' gestation and term. LASF was calculated using the formula: (end‐systolic diameter—end‐diastolic diameter)/end‐systolic diameter, and data were compared between diabetic women with and without fetal myocardial hypertrophy and controls.
Results
The study population comprised 53 diabetic women and 45 controls. Out of the 53 fetuses of diabetic women, 14 had myocardial hypertrophy and 39 had normal septal thickness. Gestational age at the time of examination did not differ significantly between the control group and the two diabetic subgroups (P = 0.57). Fetuses with myocardial hypertrophy presented a mean ( ± SD) LASF of 0.32 ± 0.11, those without myocardial hypertrophy 0.46 ± 0.12, and those of normal mothers 0.53 ± 0.09 (P < 0.001). A significant inverse linear correlation was observed between LASF and septal thickness (r = − 0.51, P < 0.001).
Conclusions
In diabetic pregnancies, LASF is lower in fetuses with myocardial hypertrophy than it is in those without hypertrophy and in fetuses of non‐diabetic women, suggesting that LASF could be a useful alternative parameter in the assessment of fetal diastolic function. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.6154 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66875737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66875737</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3494-12309a484a2033c9a97741b2a2eed1f236be03bd4de90a1d532128e2074590703</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVJaTZpob-g6JKSi9PRhyXrWEKaFhZyac5Glse7Cl7LlWSC_33s7JKecppheGZe5iHkK4MbBsB_TGF3o1gpP5ANk8oUoKE8IxswCgqtDD8nFyk9AYCSQn0i58wA41yXG_K0xS5Tm6O3PU37EDMOftjRLlqXfRioH2iHeUqY6LPPe2qH9rUJU6aHOTgb23V1P48Ycwzjfl5XllmD2Ts6RtwNdnAe02fysbN9wi-nekkef939vf1dbB_u_9z-3BZOSCMLxgUYKytpOQjhjDVaS9ZwyxFb1nGhGgTRtLJFA5a1peCMV8hBy9Isj4tL8v14d4zh34Qp1wefHPa9HTBMqVaq0qUWegGvj6CLIaWIXT1Gf7BxrhnUq9d68VqvXhf02-nm1Byw_Q-eRC7A1Qmwydl-0bf8nN44zhjoqloziyP37Huc3w2sHx_uX4NfAPR3j0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66875737</pqid></control><display><type>article</type><title>Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies</title><source>Wiley</source><creator>Zielinsky, P. ; Luchese, S. ; Manica, J. L. ; Piccoli, A. L. ; Nicoloso, L. H. ; Leite, M. F. ; Hagemann, L. ; Busato, A. ; Moraes, M. R.</creator><creatorcontrib>Zielinsky, P. ; Luchese, S. ; Manica, J. L. ; Piccoli, A. L. ; Nicoloso, L. H. ; Leite, M. F. ; Hagemann, L. ; Busato, A. ; Moraes, M. R.</creatorcontrib><description>Objective
To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non‐diabetic mothers.
Methods
Fetal echocardiography was performed in women with pre‐existing or gestational diabetes and in non‐diabetic controls between 25 weeks' gestation and term. LASF was calculated using the formula: (end‐systolic diameter—end‐diastolic diameter)/end‐systolic diameter, and data were compared between diabetic women with and without fetal myocardial hypertrophy and controls.
Results
The study population comprised 53 diabetic women and 45 controls. Out of the 53 fetuses of diabetic women, 14 had myocardial hypertrophy and 39 had normal septal thickness. Gestational age at the time of examination did not differ significantly between the control group and the two diabetic subgroups (P = 0.57). Fetuses with myocardial hypertrophy presented a mean ( ± SD) LASF of 0.32 ± 0.11, those without myocardial hypertrophy 0.46 ± 0.12, and those of normal mothers 0.53 ± 0.09 (P < 0.001). A significant inverse linear correlation was observed between LASF and septal thickness (r = − 0.51, P < 0.001).
Conclusions
In diabetic pregnancies, LASF is lower in fetuses with myocardial hypertrophy than it is in those without hypertrophy and in fetuses of non‐diabetic women, suggesting that LASF could be a useful alternative parameter in the assessment of fetal diastolic function. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.6154</identifier><identifier>PMID: 19012275</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Cardiomegaly - diagnostic imaging ; Cardiomegaly - physiopathology ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes Mellitus - diagnostic imaging ; Diabetes Mellitus - physiopathology ; Diabetes. Impaired glucose tolerance ; Echocardiography ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; fetal diastolic function ; Fetal Diseases - diagnostic imaging ; Fetal Diseases - physiopathology ; Fetal Heart - diagnostic imaging ; Fetal Heart - physiopathology ; fetal myocardial hypertrophy ; Gynecology. Andrology. Obstetrics ; Heart Atria - diagnostic imaging ; Heart Atria - physiopathology ; Humans ; left atrial shortening fraction ; maternal diabetes ; Medical sciences ; Myocardial Contraction ; Pregnancy ; Pregnancy in Diabetics ; Ultrasonography, Prenatal ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Ultrasound in obstetrics & gynecology, 2009-02, Vol.33 (2), p.182-187</ispartof><rights>Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3494-12309a484a2033c9a97741b2a2eed1f236be03bd4de90a1d532128e2074590703</citedby><cites>FETCH-LOGICAL-c3494-12309a484a2033c9a97741b2a2eed1f236be03bd4de90a1d532128e2074590703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21107887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19012275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zielinsky, P.</creatorcontrib><creatorcontrib>Luchese, S.</creatorcontrib><creatorcontrib>Manica, J. L.</creatorcontrib><creatorcontrib>Piccoli, A. L.</creatorcontrib><creatorcontrib>Nicoloso, L. H.</creatorcontrib><creatorcontrib>Leite, M. F.</creatorcontrib><creatorcontrib>Hagemann, L.</creatorcontrib><creatorcontrib>Busato, A.</creatorcontrib><creatorcontrib>Moraes, M. R.</creatorcontrib><title>Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non‐diabetic mothers.
Methods
Fetal echocardiography was performed in women with pre‐existing or gestational diabetes and in non‐diabetic controls between 25 weeks' gestation and term. LASF was calculated using the formula: (end‐systolic diameter—end‐diastolic diameter)/end‐systolic diameter, and data were compared between diabetic women with and without fetal myocardial hypertrophy and controls.
Results
The study population comprised 53 diabetic women and 45 controls. Out of the 53 fetuses of diabetic women, 14 had myocardial hypertrophy and 39 had normal septal thickness. Gestational age at the time of examination did not differ significantly between the control group and the two diabetic subgroups (P = 0.57). Fetuses with myocardial hypertrophy presented a mean ( ± SD) LASF of 0.32 ± 0.11, those without myocardial hypertrophy 0.46 ± 0.12, and those of normal mothers 0.53 ± 0.09 (P < 0.001). A significant inverse linear correlation was observed between LASF and septal thickness (r = − 0.51, P < 0.001).
Conclusions
In diabetic pregnancies, LASF is lower in fetuses with myocardial hypertrophy than it is in those without hypertrophy and in fetuses of non‐diabetic women, suggesting that LASF could be a useful alternative parameter in the assessment of fetal diastolic function. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Cardiomegaly - diagnostic imaging</subject><subject>Cardiomegaly - physiopathology</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - diagnostic imaging</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Echocardiography</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>fetal diastolic function</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetal Diseases - physiopathology</subject><subject>Fetal Heart - diagnostic imaging</subject><subject>Fetal Heart - physiopathology</subject><subject>fetal myocardial hypertrophy</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Atria - physiopathology</subject><subject>Humans</subject><subject>left atrial shortening fraction</subject><subject>maternal diabetes</subject><subject>Medical sciences</subject><subject>Myocardial Contraction</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics</subject><subject>Ultrasonography, Prenatal</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kE1r3DAQhkVJaTZpob-g6JKSi9PRhyXrWEKaFhZyac5Glse7Cl7LlWSC_33s7JKecppheGZe5iHkK4MbBsB_TGF3o1gpP5ANk8oUoKE8IxswCgqtDD8nFyk9AYCSQn0i58wA41yXG_K0xS5Tm6O3PU37EDMOftjRLlqXfRioH2iHeUqY6LPPe2qH9rUJU6aHOTgb23V1P48Ycwzjfl5XllmD2Ts6RtwNdnAe02fysbN9wi-nekkef939vf1dbB_u_9z-3BZOSCMLxgUYKytpOQjhjDVaS9ZwyxFb1nGhGgTRtLJFA5a1peCMV8hBy9Isj4tL8v14d4zh34Qp1wefHPa9HTBMqVaq0qUWegGvj6CLIaWIXT1Gf7BxrhnUq9d68VqvXhf02-nm1Byw_Q-eRC7A1Qmwydl-0bf8nN44zhjoqloziyP37Huc3w2sHx_uX4NfAPR3j0g</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Zielinsky, P.</creator><creator>Luchese, S.</creator><creator>Manica, J. L.</creator><creator>Piccoli, A. L.</creator><creator>Nicoloso, L. H.</creator><creator>Leite, M. F.</creator><creator>Hagemann, L.</creator><creator>Busato, A.</creator><creator>Moraes, M. R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies</title><author>Zielinsky, P. ; Luchese, S. ; Manica, J. L. ; Piccoli, A. L. ; Nicoloso, L. H. ; Leite, M. F. ; Hagemann, L. ; Busato, A. ; Moraes, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3494-12309a484a2033c9a97741b2a2eed1f236be03bd4de90a1d532128e2074590703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Cardiomegaly - diagnostic imaging</topic><topic>Cardiomegaly - physiopathology</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - diagnostic imaging</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Echocardiography</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>fetal diastolic function</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetal Diseases - physiopathology</topic><topic>Fetal Heart - diagnostic imaging</topic><topic>Fetal Heart - physiopathology</topic><topic>fetal myocardial hypertrophy</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Atria - physiopathology</topic><topic>Humans</topic><topic>left atrial shortening fraction</topic><topic>maternal diabetes</topic><topic>Medical sciences</topic><topic>Myocardial Contraction</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics</topic><topic>Ultrasonography, Prenatal</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zielinsky, P.</creatorcontrib><creatorcontrib>Luchese, S.</creatorcontrib><creatorcontrib>Manica, J. L.</creatorcontrib><creatorcontrib>Piccoli, A. L.</creatorcontrib><creatorcontrib>Nicoloso, L. H.</creatorcontrib><creatorcontrib>Leite, M. F.</creatorcontrib><creatorcontrib>Hagemann, L.</creatorcontrib><creatorcontrib>Busato, A.</creatorcontrib><creatorcontrib>Moraes, M. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zielinsky, P.</au><au>Luchese, S.</au><au>Manica, J. L.</au><au>Piccoli, A. L.</au><au>Nicoloso, L. H.</au><au>Leite, M. F.</au><au>Hagemann, L.</au><au>Busato, A.</au><au>Moraes, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>33</volume><issue>2</issue><spage>182</spage><epage>187</epage><pages>182-187</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objective
To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non‐diabetic mothers.
Methods
Fetal echocardiography was performed in women with pre‐existing or gestational diabetes and in non‐diabetic controls between 25 weeks' gestation and term. LASF was calculated using the formula: (end‐systolic diameter—end‐diastolic diameter)/end‐systolic diameter, and data were compared between diabetic women with and without fetal myocardial hypertrophy and controls.
Results
The study population comprised 53 diabetic women and 45 controls. Out of the 53 fetuses of diabetic women, 14 had myocardial hypertrophy and 39 had normal septal thickness. Gestational age at the time of examination did not differ significantly between the control group and the two diabetic subgroups (P = 0.57). Fetuses with myocardial hypertrophy presented a mean ( ± SD) LASF of 0.32 ± 0.11, those without myocardial hypertrophy 0.46 ± 0.12, and those of normal mothers 0.53 ± 0.09 (P < 0.001). A significant inverse linear correlation was observed between LASF and septal thickness (r = − 0.51, P < 0.001).
Conclusions
In diabetic pregnancies, LASF is lower in fetuses with myocardial hypertrophy than it is in those without hypertrophy and in fetuses of non‐diabetic women, suggesting that LASF could be a useful alternative parameter in the assessment of fetal diastolic function. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19012275</pmid><doi>10.1002/uog.6154</doi><tpages>6</tpages></addata></record> |
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| source | Wiley |
| subjects | Biological and medical sciences Cardiomegaly - diagnostic imaging Cardiomegaly - physiopathology Case-Control Studies Cross-Sectional Studies Diabetes Mellitus - diagnostic imaging Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance Echocardiography Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female fetal diastolic function Fetal Diseases - diagnostic imaging Fetal Diseases - physiopathology Fetal Heart - diagnostic imaging Fetal Heart - physiopathology fetal myocardial hypertrophy Gynecology. Andrology. Obstetrics Heart Atria - diagnostic imaging Heart Atria - physiopathology Humans left atrial shortening fraction maternal diabetes Medical sciences Myocardial Contraction Pregnancy Pregnancy in Diabetics Ultrasonography, Prenatal Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies |
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