Sarcoidosis Manifesting as Massive Splenomegaly: A Rare Occurrence

Sarcoidosis is a multisystemic granulomatous disease of unknown origin occurring worldwide and affecting people of all races and ages. This disease manifests most frequently with bilateral hilar lymphadenopathy, pulmonary infiltrates, and skin and ocular lesions. Granulomatous inflammation of the sp...

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Bibliographic Details
Published in:The American journal of the medical sciences 2004-09, Vol.328 (3), p.170-172
Main Authors: Mohan, Anant, Sood, Rita, Shariff, Nasir, Dutta, Amit Kumar, Singh Gulati, Manpreet, Gupta, Siddharth Datta
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Contrast Media
Female
General aspects
Humans
Low-attenuation nodules
Lymph Nodes - pathology
Massive splenomegaly
Medical sciences
Sarcoidosis
Sarcoidosis - diagnostic imaging
Sarcoidosis - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Splenomegaly - diagnostic imaging
Splenomegaly - etiology
Tomography, X-Ray Computed
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Summary:Sarcoidosis is a multisystemic granulomatous disease of unknown origin occurring worldwide and affecting people of all races and ages. This disease manifests most frequently with bilateral hilar lymphadenopathy, pulmonary infiltrates, and skin and ocular lesions. Granulomatous inflammation of the spleen is common in patients with sarcoidosis, but splenic enlargement is unusual and massive splenomegaly quite rare. Splenomegaly is usually homogeneous, but multiple low-attenuating nodular lesions are occasionally seen and easily mistaken for lymphoma, metastases, or infections such as tuberculosis. We describe an unusual case of sarcoidosis in a woman who presented with massive splenomegaly with extensive nodularity that cleared completely with corticosteroid therapy.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200409000-00007