Metastatic Breast Cancer: Overall Survival Related to Successive Chemotherapies. What Do We Gain After the Third Line?

This retrospective study analyzed, in metastatic breast cancer (MBC), overall survival (OS) related to each subsequent line of chemotherapy (CT). We evaluated 578 patients with a MBC. Among these patients, 558 patients were stratified according to the number of differents CT lines received. Median O...

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Bibliographic Details
Published in:Cancer investigation 2009, Vol.27 (1), p.81-85
Main Authors: Tacca, Olivier, LeHeurteur, Marianne, Durando, Xavier, Mouret-Reynier, Marie-Ange, Abrial, Catherine, Thivat, Emilie, Bayet-Robert, Mathilde, Penault-Llorca, Frederique, Chollet, Phillippe
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Chemotherapy, Adjuvant
Female
Humans
Metastatic breast cancer
Neoplasm Staging
Overall survival
Prognosis
Prospective Studies
Response to treatment
Retrospective Studies
Salvage chemotherapies
Salvage Therapy
Survival Rate
Time Factors
Time to treatment failure
Treatment Outcome
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Summary:This retrospective study analyzed, in metastatic breast cancer (MBC), overall survival (OS) related to each subsequent line of chemotherapy (CT). We evaluated 578 patients with a MBC. Among these patients, 558 patients were stratified according to the number of differents CT lines received. Median OS decreased from 22.5 to 12.3 months. Nevertheless, survival was rather stable for subsequent lines after the third line of CT around 8 months. In our study, it appeared useful to give several CT lines when possible. Subsequent lines of CT could have a beneficial effect on the survival for some patients with MBC.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357900802290580