Measurement of nuchal volume in the first trimester Down screening using three-dimensional ultrasound

Objectives Screening of fetuses at 11 to 14 weeks of gestation for Down syndrome using stored volumes acquired by a three‐dimensional (3D) scanner. Method Thirty‐four healthy singleton fetuses were recruited consecutively and prospectively during routine first trimester scans in our unit. Two‐dimens...

Full description

Saved in:
Bibliographic Details
Published in:Prenatal diagnosis 2009-01, Vol.29 (1), p.69-73
Main Authors: Shaw, Sheng-Wen, Hsieh, T'sang-T'ang, Hsu, Jenn-Jeih, Lee, Chyi-Long, Cheng, Po-Jen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cohort Studies
Delivery. Postpartum. Lactation
Down syndrome
Down Syndrome - diagnostic imaging
Female
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Gynecology. Andrology. Obstetrics
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Medical sciences
Molecular and cellular biology
nuchal translucency
Nuchal Translucency Measurement - methods
Pilot Projects
Pregnancy
Pregnancy Trimester, First
volume
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Screening of fetuses at 11 to 14 weeks of gestation for Down syndrome using stored volumes acquired by a three‐dimensional (3D) scanner. Method Thirty‐four healthy singleton fetuses were recruited consecutively and prospectively during routine first trimester scans in our unit. Two‐dimensional (2D) images of nuchal translucency (NT), crown‐rump length (CRL), and biparietal diameter (BPD) were obtained by following a standard protocol. The volume of the nuchal area (NV) was obtained by a 3D scanning machine. Results The mean time to perform a 2D first trimester scan was 15.3 min, while the mean time to obtain and examine the stored volumes was 11.1 min (p < 0.001) in a 3D scan. There were no significant differences in NT, CRL, and BPD between the two groups. Two cases with an NT thickness > 2.5 mm also revealed increased volume data in the nuchal area. The Pearson's correlations between NT and CRL, BPD and CRL, NT and NV, and NV and CRL were moderate‐to‐high positive. Conclusion The nuchal volume data and the standard curve in the first trimester may be possible markers for Down syndrome screening. 3D scans can also minimize the scanning time, providing views not easily following strict NT guidelines. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.2120