Ophthalmic manifestations in Langerhans cell histiocytosis

Histiocytosis of childhood is characterized by localized or generalized proliferation of cells of the mononuclear phagocyte system and the dendritic cell system. In patients with Langerhans cell histiocytosis, the orbit is the most involved site encountered in ophthalmic practice, usually as a lytic...

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Bibliographic Details
Published in:The Israel Medical Association journal 2004-09, Vol.6 (9), p.553-555
Main Authors: Levy, Jaime, Monos, Tova, Kapelushnik, Joseph, Maor, Esther, Nash, Michael, Lifshitz, Tova
Format: Article
Language:English
Subjects:
Eye Diseases - etiology
Histiocytosis, Langerhans-Cell - complications
Histiocytosis, Langerhans-Cell - diagnosis
Humans
Orbital Diseases - etiology
Orbital Diseases - therapy
Prognosis
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Summary:Histiocytosis of childhood is characterized by localized or generalized proliferation of cells of the mononuclear phagocyte system and the dendritic cell system. In patients with Langerhans cell histiocytosis, the orbit is the most involved site encountered in ophthalmic practice, usually as a lytic lesion in the zygomaticofrontal suture. Patients usually present with acute or chronic periorbital swelling. Electron microscopic findings of Birbeck granules and positive staining for CD1 antigenic determinant confirm the diagnosis.
ISSN:1565-1088