A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes

A diffuse reflectance spectroscopy system was modified as a step towards miniaturization and spectral imaging of tissue absorption and scattering. The modified system uses a tunable source and an optical fiber for illumination and a photodiode in contact with tissue for detection. Compared to the pr...

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Bibliographic Details
Published in:Optics express 2009-02, Vol.17 (3), p.1372-1384
Main Authors: Lo, Justin Y, Yu, Bing, Fu, Henry L, Bender, Janelle E, Palmer, Gregory M, Kuech, Thomas F, Ramanujam, Nirmala
Format: Article
Language:English
Subjects:
Absorption - radiation effects
Computer Simulation
Hemoglobins - metabolism
Humans
Light
Monte Carlo Method
Optics and Photonics - instrumentation
Phantoms, Imaging
Scattering, Radiation
Spectrum Analysis - methods
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Summary:A diffuse reflectance spectroscopy system was modified as a step towards miniaturization and spectral imaging of tissue absorption and scattering. The modified system uses a tunable source and an optical fiber for illumination and a photodiode in contact with tissue for detection. Compared to the previous system, it is smaller, less costly, and has comparable performance in extracting optical properties in tissue phantoms. Wavelength reduction simulations show the feasibility of replacing the source with LEDs to further decrease system size and cost. Simulated crosstalk analysis indicates that this evolving system can be multiplexed for spectral imaging in the future.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.17.001372