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High prevalence of rheumatoid factor associated with clinical manifestations of rheumatic disease in Kaingang and Guarani Indians from Southern Brazil
The aim of the present study was to perform a screening for rheumatoid factor (RF) and anti-nuclear antibody in Kaingang, Guarani and Mestizos individuals from Mangueirinha Reservation, State of Paraná, Brazil, and associate it with demographic and clinical data. Serum samples from 321 aborigines (1...
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| Published in: | Rheumatology international 2009-02, Vol.29 (4), p.427-430 |
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| container_title | Rheumatology international |
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| creator | Ribas, João Luiz Coelho da Rosa Utiyama, Shirley Ramos Nisihara, Renato Mitsunori Boeira, Maristela de Messias Reason, Iara Taborda |
| description | The aim of the present study was to perform a screening for rheumatoid factor (RF) and anti-nuclear antibody in Kaingang, Guarani and Mestizos individuals from Mangueirinha Reservation, State of Paraná, Brazil, and associate it with demographic and clinical data. Serum samples from 321 aborigines (125♂ and 196♀; 4–86 years old) and 180 non-Indians healthy individuals were analysed (62♂ and 118♀; 2–81 years old). Antinuclear antibody (ANA) was tested by indirect immunofluorescence, and RF by agglutination in latex and turbidimetry. RF was higher in Kaingang when compared to Guarani (
P
= 0.009), Mestizos (
P
= 0.061) and non-Indians (
P
= 0.010). A significant increase of RF was observed in Kaingang women versus Kaingang men (
P
= 0.002) and, among the women, in Kaingang when compared to Mestizos and Guarani (
P
≤ 0.008). The positivity for ANA did not show significant differences between the groups. Clinical evaluation of RF positive individuals (
n
= 6) confirmed rheumatoid arthritis in two Kaingang Indians. Other two individuals (RF positive) will be under medical observation, as well as two Mestizos. The differences observed among the investigated groups, suggest the influence of genetic and hormonal factors in the development of auto antibodies in these populations. |
| doi_str_mv | 10.1007/s00296-008-0716-3 |
| format | article |
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P
= 0.009), Mestizos (
P
= 0.061) and non-Indians (
P
= 0.010). A significant increase of RF was observed in Kaingang women versus Kaingang men (
P
= 0.002) and, among the women, in Kaingang when compared to Mestizos and Guarani (
P
≤ 0.008). The positivity for ANA did not show significant differences between the groups. Clinical evaluation of RF positive individuals (
n
= 6) confirmed rheumatoid arthritis in two Kaingang Indians. Other two individuals (RF positive) will be under medical observation, as well as two Mestizos. The differences observed among the investigated groups, suggest the influence of genetic and hormonal factors in the development of auto antibodies in these populations.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-008-0716-3</identifier><identifier>PMID: 18820931</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Antibodies, Antinuclear - analysis ; Arthritis ; Autoantibodies - analysis ; Brazil - epidemiology ; Ethnic Groups - genetics ; Female ; Fluorescent Antibody Technique, Indirect ; Geography ; Humans ; Indians, South American - classification ; Indians, South American - genetics ; Latex Fixation Tests ; Male ; Medicine ; Medicine & Public Health ; Nephelometry and Turbidimetry ; Original Article ; Prevalence ; Rheumatic diseases ; Rheumatism ; Rheumatoid Factor - analysis ; Rheumatology</subject><ispartof>Rheumatology international, 2009-02, Vol.29 (4), p.427-430</ispartof><rights>Springer-Verlag 2008</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-1c4ecc5d3ccbe11315df6f535f2545607b29dba8af3d1f51a790b560635dfd63</citedby><cites>FETCH-LOGICAL-c369t-1c4ecc5d3ccbe11315df6f535f2545607b29dba8af3d1f51a790b560635dfd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18820931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribas, João Luiz Coelho</creatorcontrib><creatorcontrib>da Rosa Utiyama, Shirley Ramos</creatorcontrib><creatorcontrib>Nisihara, Renato Mitsunori</creatorcontrib><creatorcontrib>Boeira, Maristela</creatorcontrib><creatorcontrib>de Messias Reason, Iara Taborda</creatorcontrib><title>High prevalence of rheumatoid factor associated with clinical manifestations of rheumatic disease in Kaingang and Guarani Indians from Southern Brazil</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>The aim of the present study was to perform a screening for rheumatoid factor (RF) and anti-nuclear antibody in Kaingang, Guarani and Mestizos individuals from Mangueirinha Reservation, State of Paraná, Brazil, and associate it with demographic and clinical data. Serum samples from 321 aborigines (125♂ and 196♀; 4–86 years old) and 180 non-Indians healthy individuals were analysed (62♂ and 118♀; 2–81 years old). Antinuclear antibody (ANA) was tested by indirect immunofluorescence, and RF by agglutination in latex and turbidimetry. RF was higher in Kaingang when compared to Guarani (
P
= 0.009), Mestizos (
P
= 0.061) and non-Indians (
P
= 0.010). A significant increase of RF was observed in Kaingang women versus Kaingang men (
P
= 0.002) and, among the women, in Kaingang when compared to Mestizos and Guarani (
P
≤ 0.008). The positivity for ANA did not show significant differences between the groups. Clinical evaluation of RF positive individuals (
n
= 6) confirmed rheumatoid arthritis in two Kaingang Indians. Other two individuals (RF positive) will be under medical observation, as well as two Mestizos. The differences observed among the investigated groups, suggest the influence of genetic and hormonal factors in the development of auto antibodies in these populations.</description><subject>Adult</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Arthritis</subject><subject>Autoantibodies - analysis</subject><subject>Brazil - epidemiology</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Geography</subject><subject>Humans</subject><subject>Indians, South American - classification</subject><subject>Indians, South American - genetics</subject><subject>Latex Fixation Tests</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephelometry and Turbidimetry</subject><subject>Original Article</subject><subject>Prevalence</subject><subject>Rheumatic diseases</subject><subject>Rheumatism</subject><subject>Rheumatoid Factor - analysis</subject><subject>Rheumatology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u3CAYRVHVqpkkfYBuKtRFd275jI3xso3yp0bqollkhz7zM0NkwxTsROmD5HlDNCOlqpQNCDj3AjqEfAT2FRjrvmXG6l5UjMmKdSAq_oasoOFdBYLdvCUrBl1dyTIckMOcb1lZC8HekwOQsmY9hxV5vPDrDd0me4ejDdrS6Gja2GXCOXpDHeo5Joo5R-1xtobe-3lD9eiD1zjSCYN3Ns84-xjyP2GvqfHZYrbUB_oTfVhjWFMMhp4vmEqMXgbjsYRcihP9HZd5Y1OgPxL-9eMxeedwzPbDfj4i12en1ycX1dWv88uT71eV5qKfK9CN1bo1XOvBAnBojROu5a2r26YVrBvq3gwo0XEDrgXsejaUfcELaAQ_Il92tdsU_yzlH2ryWdtxxGDjkpUQUnayaQr4-T_wNi4plKcpKRuoe85kgWAH6RRzTtapbfITpgcFTD0LUzthqghTz8IUL5lP--JlmKx5SewNFaDeAbkchbVNLze_3voEHqGjsw</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Ribas, João Luiz Coelho</creator><creator>da Rosa Utiyama, Shirley Ramos</creator><creator>Nisihara, Renato Mitsunori</creator><creator>Boeira, Maristela</creator><creator>de Messias Reason, Iara Taborda</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>High prevalence of rheumatoid factor associated with clinical manifestations of rheumatic disease in Kaingang and Guarani Indians from Southern Brazil</title><author>Ribas, João Luiz Coelho ; da Rosa Utiyama, Shirley Ramos ; Nisihara, Renato Mitsunori ; Boeira, Maristela ; de Messias Reason, Iara Taborda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-1c4ecc5d3ccbe11315df6f535f2545607b29dba8af3d1f51a790b560635dfd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Arthritis</topic><topic>Autoantibodies - analysis</topic><topic>Brazil - epidemiology</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Geography</topic><topic>Humans</topic><topic>Indians, South American - classification</topic><topic>Indians, South American - genetics</topic><topic>Latex Fixation Tests</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephelometry and Turbidimetry</topic><topic>Original Article</topic><topic>Prevalence</topic><topic>Rheumatic diseases</topic><topic>Rheumatism</topic><topic>Rheumatoid Factor - analysis</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribas, João Luiz Coelho</creatorcontrib><creatorcontrib>da Rosa Utiyama, Shirley Ramos</creatorcontrib><creatorcontrib>Nisihara, Renato Mitsunori</creatorcontrib><creatorcontrib>Boeira, Maristela</creatorcontrib><creatorcontrib>de Messias Reason, Iara Taborda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribas, João Luiz Coelho</au><au>da Rosa Utiyama, Shirley Ramos</au><au>Nisihara, Renato Mitsunori</au><au>Boeira, Maristela</au><au>de Messias Reason, Iara Taborda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of rheumatoid factor associated with clinical manifestations of rheumatic disease in Kaingang and Guarani Indians from Southern Brazil</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>29</volume><issue>4</issue><spage>427</spage><epage>430</epage><pages>427-430</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>The aim of the present study was to perform a screening for rheumatoid factor (RF) and anti-nuclear antibody in Kaingang, Guarani and Mestizos individuals from Mangueirinha Reservation, State of Paraná, Brazil, and associate it with demographic and clinical data. Serum samples from 321 aborigines (125♂ and 196♀; 4–86 years old) and 180 non-Indians healthy individuals were analysed (62♂ and 118♀; 2–81 years old). Antinuclear antibody (ANA) was tested by indirect immunofluorescence, and RF by agglutination in latex and turbidimetry. RF was higher in Kaingang when compared to Guarani (
P
= 0.009), Mestizos (
P
= 0.061) and non-Indians (
P
= 0.010). A significant increase of RF was observed in Kaingang women versus Kaingang men (
P
= 0.002) and, among the women, in Kaingang when compared to Mestizos and Guarani (
P
≤ 0.008). The positivity for ANA did not show significant differences between the groups. Clinical evaluation of RF positive individuals (
n
= 6) confirmed rheumatoid arthritis in two Kaingang Indians. Other two individuals (RF positive) will be under medical observation, as well as two Mestizos. The differences observed among the investigated groups, suggest the influence of genetic and hormonal factors in the development of auto antibodies in these populations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18820931</pmid><doi>10.1007/s00296-008-0716-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Rheumatology international, 2009-02, Vol.29 (4), p.427-430 |
| issn | 0172-8172 1437-160X |
| language | eng |
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| subjects | Adult Antibodies, Antinuclear - analysis Arthritis Autoantibodies - analysis Brazil - epidemiology Ethnic Groups - genetics Female Fluorescent Antibody Technique, Indirect Geography Humans Indians, South American - classification Indians, South American - genetics Latex Fixation Tests Male Medicine Medicine & Public Health Nephelometry and Turbidimetry Original Article Prevalence Rheumatic diseases Rheumatism Rheumatoid Factor - analysis Rheumatology |
| title | High prevalence of rheumatoid factor associated with clinical manifestations of rheumatic disease in Kaingang and Guarani Indians from Southern Brazil |
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