Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

In this review, primary attention is given to the antioxidant (and prooxidant) activity of polyphenols arising from their interactions with iron both in vitro and in vivo. In addition, an overview of oxidative stress and the Fenton reaction is provided, as well as a discussion of the chemistry of ir...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2009-03, Vol.53 (2), p.75-100
Main Authors: Perron, Nathan R, Brumaghim, Julia L
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - chemistry
Antioxidants - metabolism
Antioxidants - pharmacology
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cell Biology
Copper - metabolism
DNA Damage - drug effects
Flavonoids - chemistry
Flavonoids - metabolism
Flavonoids - pharmacology
Humans
Iron
Iron - chemistry
Iron - metabolism
Life Sciences
Oxidative stress
Oxidative Stress - drug effects
Pharmacology/Toxicology
Phenols - chemistry
Phenols - metabolism
Phenols - pharmacology
Polyphenols
Review Paper
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Summary:In this review, primary attention is given to the antioxidant (and prooxidant) activity of polyphenols arising from their interactions with iron both in vitro and in vivo. In addition, an overview of oxidative stress and the Fenton reaction is provided, as well as a discussion of the chemistry of iron binding by catecholate, gallate, and semiquinone ligands along with their stability constants, UV-vis spectra, stoichiometries in solution as a function of pH, rates of iron oxidation by O₂ upon polyphenol binding, and the published crystal structures for iron-polyphenol complexes. Radical scavenging mechanisms of polyphenols unrelated to iron binding, their interactions with copper, and the prooxidant activity of iron-polyphenol complexes are briefly discussed.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-009-9043-x