Controlled Release of High Molecular Weight Hyaluronic Acid from Molecularly Imprinted Hydrogel Contact Lenses

• Published in: Pharmaceutical research 2009-03, Vol.26 (3), p.714-726
• Main Authors: Ali, Maryam, Byrne, Mark E
• Format: Article
• Language: English
• Subjects: Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; biomimetic; Biomimetic Materials - chemistry; Biomimetics; comfort contact lenses; Contact Lenses; controlled drug delivery; Delayed-Action Preparations; Drug Carriers - chemistry; Drug delivery systems; Drug Delivery Systems - methods; Drug Stability; dry eye; Dry Eye Syndromes - drug therapy; Eyes & eyesight; General pharmacology; Humans; Hyaluronic Acid - administration & dosage; Hyaluronic Acid - chemistry; Hydrogels - chemistry; Medical Law; Medical sciences; Models, Molecular; molecular imprinted hydrogel; Molecular Structure; Molecular Weight; Pharmaceutical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; Polymers; Research Paper; therapeutic contact lenses
• ISSN: 0724-8741; 1573-904X
• DOI: 10.1007/s11095-008-9818-6

Purpose Current dry eye treatment includes delivering comfort agents to the eye via drops, but low bioavailability and multiple administration continues to be a barrier to effective treatment. There exists a significant unmet need for devices to treat dry eye and for more comfortable contact lenses. Methods Using molecular imprinting strategies with an analysis of biology, we have rationally designed and synthesized hydrogel contact lenses that can release hyaluronic acid (HA) at a controlled rate. Results Delayed release characteristics were significantly improved through biomimetic imprinting, as multiple functional monomers provided non-covalent complexation points within nelfilcon A gels without altering structural, mechanical, or optical properties. The diffusion coefficient of 1.2 million Dalton HA was controlled by varying the number and variety of functional monomers (increasing the variety lowered the HA diffusion coefficient 1.5 times more than single functional monomers, and 1.6 times more than nelfilcon A alone). Conclusions HA can be delivered from a daily disposable lens at a therapeutic rate of approximately 6 μg/h for 24 h. This is the first demonstration of imprinting a large molecular weight polymer within a hydrogel and the effect of imprinting on the reptation of the long chain macromolecule from the structure.