Evidence of Left Ventricular Dysfunction in Asymptomatic Elderly Patients with Non-insulin-dependent Diabetes Mellitus

• Published in: Angiology 2004-09, Vol.55 (5), p.549-555
• Main Authors: Karvounis, Haralampos I., Papadopoulos, Christodoulos E., Zaglavara, Theodora A., Nouskas, Ioannis G., Gemitzis, Konstantinos D., Parharidis, Georgios E., Louridas, Georgios E.
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Biological and medical sciences; Blood and lymphatic vessels; Blood Glucose - analysis; Cardiology. Vascular system; Data Interpretation, Statistical; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Echocardiography; Echocardiography, Doppler; Female; Glycated Hemoglobin A - analysis; Heart Rate; Humans; Male; Medical sciences; Middle Aged; Sex Factors; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/000331970405500511

Diabetic cardiomyopathy is a distinct entity in diabetic patients with congestive heart failure, who have no angiographic evidence of significant coronary artery stenosis. The aim of this study was to evaluate left ventricular (LV) function in 24 elderly patients (mean age 67 ±2 years) with type 2 diabetes, who were asymptomatic and had no history of hypertension, or coronary or valvular heart disease. LV systolic indices (ejection fraction [EF] and fractional shortening [FS]), diastolic indices (E wave, A wave, E/A ratio, isovolumic relaxation time [IVRT] and deceleration time [DT]) and the myocardial performance index (MPI) were evaluated with echocardiography. Compared to controls (24 age- and gender-matched normal subjects), the E wave was reduced (0.60 ±0.10 m/sec vs 0.72 ±0.08 m/sec, p