SUSCEPTIBILITIES OF BACTERIA ISOLATED FROM PATIENTS WITH LOWER RESPIRATORY INFECTIOUS DISEASES TO ANTIBIOTICS(2002)

• Published in: Japanese journal of antibiotics 2004/06/25, Vol.57(3), pp.213-245
• Main Authors: SHIMADA, KAORU, NAKANO, KUNIO, IGARI, JUN, OGURI, TOYOKO, IDEMOTO, HIDEO, MORI, TAKESHI, YOKOUCHI, HIROSHI, YAMAMOTO, MAKOTO, INOUE, HIROSHI, NAKADATE, TOSHIHIDE, SUWABE, AKIRA, OKADA, SHINJI, ASHINO, YUGO, GEJYO, FUMITAKE, OKADA, MASAHIKO, AOKI, NOBUKI, KITAMURA, NOBUKO, SUZUKI, YASUTOSHI, KARASAWA, YASUO, NADATA, KOICHIRO, NADATANI, TATSUO, INAGAWA, HIROKO, KUDO, KOUICHIRO, KOBAYASHI, NOBUYUKI, TANAKA, TSUKASA, KOBAYASHI, HIROYUKI, GOTO, HAJIME, KAWAI, SHIN, TAKEDA, HIDENORI, SUMITOMO, MIDORI, MATSUSHIMA, TOSHIHARU, NIKI, YOSHIHITO, KOHNO, SHIGERU, MIYAZAKI, YOSHITUGU, YANAGIHARA, KATSUNORI, HIRAKATA, YOICHI, MATSUDA, JUNICHI, NASU, MASARU, HIRAMATSU, KAZUFUMI, SUGA, MORITAKA, TOSAKA, MASAKAZU
• Format: Article
• Language: Japanese
• Subjects: Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacteria - isolation & purification; Drug Resistance, Bacterial; Humans; Respiratory Tract Infections - microbiology; Time Factors
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.57.213

From October 2002 to September 2003, we collected the specimen from 476 patients with lower respiratory tract infections in 16 institutions in Japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. Of 584 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in inflammation, 578 strains were examined. The breakdown of the isolated bacteria were: Staphylococcus aureus 77, Streptococcus pneumoniae 103, Haemophilus influenzae 95, Pseudomonas aeruginosa (non-mucoid) 61, P. aeruginosa (mucoid) 23, Klebsiella pneumoniae 36, 1 29, etc. Of 77 S. aureus strains, those with 2μg/ml or less of MIC of oxacillin (MPIPC) [methicillin-susceptible S. aureus: MSSA] was 34 strains (44.2%) and those with 4μg/ml or more of MIC of oxacillin (methicillin-resistant S. aureus: MRSA) was 43 strains (55.8%). Against MSSA, imipenem (IPM) and minocycline (MINO) had the most potent antibacterial activity and inhibited the growth of all the strains at 0.25μg/ml. Although clindamycin (CLDM) and aminoglycosides also had the potent activity, the resistant strains against those agents were detected. Cefotiam (CTM) inhibited the growth of all the strains at 1μg/ml without the low sensitive strains. Against MRSA, vancomycin (VCM) showed the most potent activity and inhibited the growth of all the strains at 2μg/ml. Arbekacin (ABK) also showed the relatively potent activity and inhibited the growth of all the strains at 4μg/ml. Carbapenems showed the most potent activities against S. pneumoniae and inhibited the growth of all the strains at 0.25-0.5μg/ml. Cefozopran (CZOP) also had a preferable activity (MIC90: 1μg/ml) and inhibitedthe growth of all the strains at 2μg/ml. In contrast, the resistant strains for cefaclor (CCL), erythromycin (EM), CLDM, and tetracycline (TC) were detected in 50.5%, 76.7%, 50.5%, and 80.6% of all the strains, respectively. Against H. influenzae, LVFX showed the most potent activity and inhibited the growth of 92 of all the strains (96.8%) at 0.063 ug/ml. Tobramycin (TOB) showed the most potent activity against P. aeruginosa (both mucoid and non-mucoid) and inhibited the growth of all the strains at 2μg/ml. The antibacterial activity of CZOP was good and its MIC90 against mucoid and non-mucoid strains was 8 and 16μg/ml, respectively. CZOP and cefpirome (CPR) were the most potent against K. pneumoniae with 0.125μg/ml of MIC90. Also, all the agents gen