COMBINED EFFECTS OF ARBEKACIN WITH BIAPENEM AGAINST IN VITRO AND IN VIVO MODEL OF A MIXTURE OF MRSA AND Pseudomonas aeruginosa

Combinede ffectso f arbekacin (A BK) with biapenem (BIPM) w eree xaminedo n both i n vitro and in vivo model of a mixtureo f MRSA and Pseudomonaase ruginosa As a result, significan etffect in vitrow aso bserved in combined use of ABK (1/2 MIC) with BIPM (1/4 and 1/2 MIC) against MRSA as compared wit...

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Bibliographic Details
Published in:Japanese journal of antibiotics 2004/06/25, Vol.57(3), pp.288-293
Main Authors: NIIDA, MASASHI, SAKAKIBARA, SHIROU, KAWABATA, TOSHIE, MAEBASHI, KAZUNORI, TAKATA, TOSHIHIKO, HIKIDA, MUNEO
Format: Article
Language:Japanese
Subjects:
Aminoglycosides - pharmacology
Aminoglycosides - therapeutic use
Animals
Anti-Infective Agents - pharmacology
Dibekacin - analogs & derivatives
Dibekacin - pharmacology
Dibekacin - therapeutic use
Disease Models, Animal
Drug Combinations
Drug Resistance, Bacterial
Drug Therapy, Combination
Male
Methicillin Resistance
Mice
Mice, Inbred ICR
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - complications
Pseudomonas Infections - drug therapy
Staphylococcal Infections - complications
Staphylococcal Infections - drug therapy
Staphylococcus aureus - drug effects
Thienamycins - pharmacology
Thienamycins - therapeutic use
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Summary:Combinede ffectso f arbekacin (A BK) with biapenem (BIPM) w eree xaminedo n both i n vitro and in vivo model of a mixtureo f MRSA and Pseudomonaase ruginosa As a result, significan etffect in vitrow aso bserved in combined use of ABK (1/2 MIC) with BIPM (1/4 and 1/2 MIC) against MRSA as compared with ABK or BIPM alone. Against P aeruginosa combined effect was also observed, showing reduction of viable cells to the limitation of detection within 2 hours. Moreover, with respect to the protective effect on mixed systemic infection of MRSA and P aeruginosa, the combined treatment with ABK and BIPM showed more excellent efficacy as compared with the single use of each drug.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.57.288