Volumetric Investigation of the Frontal-Subcortical Circuitry in Patients With Obsessive-Compulsive Disorder

The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the pu...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2004, Vol.16 (3), p.342-349
Main Authors: Kang, Do-Hyung, Kim, Jae-Jin, Choi, Jung-Seok, Kim, Young Il, Kim, Chi-Won, Youn, Tak, Han, Moon Hee, Chang, Kee-Hyun, Kwon, Jun Soo
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Brain - pathology
Brain Mapping
Case-Control Studies
Female
Frontal Lobe - pathology
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Male
Medical sciences
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - pathology
Obsessive-Compulsive Disorder - physiopathology
Obsessive-compulsive disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and sex-matched OCD patients and normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. The left orbitofrontal volumes were found to be significantly smaller in the OCD patients and showed significant negative correlations with obsessive-compulsive symptom severity. These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.16.3.342