BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growt...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2004-10, Vol.27 (10), p.589-594
Main Authors: Mattson, Mark P., Maudsley, Stuart, Martin, Bronwen
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult and adolescent clinical studies
Aging - metabolism
Animals
Biological and medical sciences
Brain
Brain-Derived Neurotrophic Factor - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Depression
Humans
Medical sciences
Mood disorders
Neurodegenerative Diseases - metabolism
Neurological disorders
Neurology
Neuronal Plasticity
Neurons - metabolism
Pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin - metabolism
Signal Transduction
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Summary:Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2004.08.001