Role of excretory--secretory metabolites of Fasciola gigantica in modulating delayed-type hypersensitivity in rats

The role of excretory-secretory metabolites of Fasciola gigantica in modulating the delayed type of hypersensitivity in the host (rats) was investigated. Eighteen rats of either sex, aged 3-4 months, were assigned to three groups of 6 animals each. Rats in group 1 served as non-inoculated controls a...

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Bibliographic Details
Published in:Veterinary research communications 2004-07, Vol.28 (5), p.387-393
Main Authors: Ganga, G, Varshney, J.P, Sharma, R.L
Format: Article
Language:English
Subjects:
Animals
antigens
Biopsy
delayed hypersensitivity
excretion
excretory-secretory products
Fasciola gigantica
Fasciola hepatica - cytology
Fasciola hepatica - immunology
Fasciola hepatica - physiology
fascioliasis
histopathology
Hypersensitivity, Delayed - pathology
Hypersensitivity, Delayed - prevention & control
Hypersensitivity, Delayed - veterinary
immunomodulators
laboratory animals
liver flukes
lymphocyte proliferation
metabolites
Rats
Rodent Diseases - immunology
Rodent Diseases - prevention & control
secretion
skin
Skin Tests - veterinary
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Summary:The role of excretory-secretory metabolites of Fasciola gigantica in modulating the delayed type of hypersensitivity in the host (rats) was investigated. Eighteen rats of either sex, aged 3-4 months, were assigned to three groups of 6 animals each. Rats in group 1 served as non-inoculated controls and each rat in this group was administered only Freund's complete adjuvant on day 7. Animals in groups 2 and 3 were administered inoculation dose(s) of somatic F gigantica antigen (SFgA) and excretory-secretory F gigantica antigens (ESFgA) according to the experimental schedule. The delayed-type hypersensitivity was monitored by assessing alterations in the foot pad thickness, its histopathology and lymphocyte proliferation assay. It was observed that the ESFgA caused diminution in delayed-type hypersensitivity response to a significant level (p
ISSN:0165-7380
1573-7446
DOI:10.1023/B:VERC.0000035025.79686.05