Alterations in platelet serotonin transporter binding in women with postpartum onset major depression

There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, plate...

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Bibliographic Details
Published in:Journal of psychiatric research 2004-09, Vol.38 (5), p.467-473
Main Authors: Newport, D.Jeffrey, Owens, Michael J., Knight, David L., Ragan, Kim, Morgan, Neal, Nemeroff, Charles B., Stowe, Zachary N.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Carrier Proteins - physiology
Case-Control Studies
Depression
Depression, Postpartum - physiopathology
Female
Humans
Major depression
Medical sciences
Mood disorders
Platelet
Postpartum
Pregnancy
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin
Serotonin - pharmacokinetics
Serotonin Plasma Membrane Transport Proteins
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Summary:There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, platelet serotonin transporter (SERT) binding was assessed using [ 3H]paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. Significant differences were detected among the 4 groups with respect to the dissociation constant ( K d) of platelet binding sites for [ 3H]paroxetine with the highest K d values among those with PPD. The density ( B max) of platelet binding sites for [ 3H]paroxetine did not differ between the study groups. These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2004.01.011