Administration of donor‐derived transplant acceptance‐inducing cells to the recipients of renal transplants from deceased donors is technically feasible

:  Patient KW, a 36‐yr‐old male renal transplant recipient, received transplant acceptance‐inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post‐transplantation, the patient’s conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk po...

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Bibliographic Details
Published in:Clinical transplantation 2009-01, Vol.23 (1), p.140-145
Main Authors: Hutchinson, James A., Gövert, Felix, Riquelme, Paloma, Bräsen, Jan Hinrich, Brem‐Exner, Beate G., Matthäi, Martina, Schulze, Maren, Renders, Lutz, Kunzendorf, Ulrich, Geissler, Edward K., Fändrich, Fred
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cadaver
Cell- and Tissue-Based Therapy
cell‐based immunotherapy
Feasibility Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
HLA Antigens - immunology
Humans
Immunosuppressive Agents - therapeutic use
Kidney Transplantation - immunology
Male
Medical sciences
regulatory macrophage
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tacrolimus - therapeutic use
Tissue Donors
Tissue, organ and graft immunology
Transplantation Conditioning
Transplantation Tolerance - immunology
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Summary::  Patient KW, a 36‐yr‐old male renal transplant recipient, received transplant acceptance‐inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post‐transplantation, the patient’s conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post‐transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four‐yr follow‐up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2008.00953.x