Legioliulin, a new isocoumarin compound responsible for blue-white autofluorescence in Legionella (Fluoribacter) dumoffii under long-wavelength UV light

Legionella dumoffii is one of the causative agents of Legionnaires’ disease. There are 50 species in the genus Legionella, of which 10 species including L. dumoffii are known to exhibit uncharacterized blue-white autofluorescence. We constructed an L. dumoffii strain that exhibited a high intensity...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-10, Vol.323 (3), p.954-959
Main Authors: Amemura-Maekawa, Junko, Hayakawa, Yoichi, Sugie, Hajime, Moribayashi, Atsuko, Kura, Fumiaki, Chang, Bin, Wada, Akihito, Watanabe, Haruo
Format: Article
Language:English
Subjects:
Autofluorescence
Coumarins - chemistry
Coumarins - classification
Coumarins - metabolism
Coumarins - radiation effects
Isocoumarin
Legionella
Legionella - cytology
Legionella - genetics
Legionella - metabolism
Legionella - radiation effects
Legionella dumoffii
Luminescent Measurements
Luminescent Proteins - metabolism
Luminescent Proteins - radiation effects
Magnetic Resonance Imaging
Mass spectrometry
Molecular Conformation
Molecular Weight
NMR
Polyketide
Protein Engineering
Species Specificity
Ultraviolet Rays
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Summary:Legionella dumoffii is one of the causative agents of Legionnaires’ disease. There are 50 species in the genus Legionella, of which 10 species including L. dumoffii are known to exhibit uncharacterized blue-white autofluorescence. We constructed an L. dumoffii strain that exhibited a high intensity blue-white fluorescence, isolated a fluorescent pigment from the strain, and determined its molecular formula to be C19H14O3 by high-resolution mass spectrometry. An NMR analysis revealed that this was a new isocoumarin compound, which was named legioliulin.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.08.180