The Highly Leukotoxic JP2 Clone of Actinobacillus actinomycetemcomitans and Progression of Periodontal Attachment Loss

The JP2 clone of Actinobacillus actinomycetemcomitans has been implicated in the etiology of periodontitis in adolescents. The aim of this two-year longitudinal study was to describe clinical attachment loss (CAL) progression and to assess its association with baseline occurrence of the JP2 and non-...

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Bibliographic Details
Published in:Journal of dental research 2004-10, Vol.83 (10), p.767-770
Main Authors: Haubek, D., Ennibi, O.-K., Poulsen, K., Benzarti, N., Baelum, V.
Format: Article
Language:English
Subjects:
Actinobacillus actinomycetemcomitans
Adolescent
Aggregatibacter actinomycetemcomitans - genetics
Aggregatibacter actinomycetemcomitans - pathogenicity
Aggressive Periodontitis - epidemiology
Aggressive Periodontitis - microbiology
Bacterial Toxins
Case-Control Studies
Clone Cells
Dental Plaque - microbiology
Dentistry
Disease Progression
Female
Humans
Longitudinal Studies
Male
Molecular Epidemiology
Morocco - epidemiology
Odds Ratio
Periodontal Attachment Loss - microbiology
Species Specificity
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Summary:The JP2 clone of Actinobacillus actinomycetemcomitans has been implicated in the etiology of periodontitis in adolescents. The aim of this two-year longitudinal study was to describe clinical attachment loss (CAL) progression and to assess its association with baseline occurrence of the JP2 and non-JP2 types of A. actinomycetemcomitans. Clinical re-examination of 121 adolescents in Morocco was performed. Progression of CAL ≥ 1 mm, ≥ 2 mm, ≥ 3 mm, and ≥ 4 mm on at least one site was found in 58%, 48%, 22%, and 6% of the subjects, respectively. Subjects who, at baseline, harbored the JP2 clone had a significantly higher progression of CAL than did subjects harboring non-JP2 types of A. actinomycetemcomitans. Subjects harboring non-JP2 types displayed a marginally higher CAL progression than did subjects who were culture-negative for A. actinomycetemcomitans.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910408301006