Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a qua...

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Bibliographic Details
Published in:Epilepsy & behavior 2004-10, Vol.5 (5), p.687-695
Main Authors: Reminger, Sheryl L., Kaszniak, Alfred W., Labiner, David M., Littrell, Lindsey D., David, Brian T., Ryan, Lee, Herring, Anne M., Kaemingk, Kris L.
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - therapeutic use
Epilepsy, Temporal Lobe - drug therapy
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - psychology
Female
Functional Laterality - physiology
Hippocampus
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Male
Memory
Memory - physiology
Neuropsychological Tests
Neuropsychology
Predictive Value of Tests
Quality of Life
Temporal lobe epilepsy
Verbal Learning - physiology
Visual Perception - physiology
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Summary:The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2004.06.006