Microneedle insertion force reduction using vibratory actuation

The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to ins...

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Bibliographic Details
Published in:Biomedical microdevices 2004-09, Vol.6 (3), p.177-182
Main Authors: Yang, Ming, Zahn, Jeffrey D
Format: Article
Language:English
Subjects:
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Equipment Design
Equipment Failure Analysis
Injections - instrumentation
Injections - methods
Microinjections - instrumentation
Microinjections - methods
Micromanipulation - instrumentation
Micromanipulation - methods
Miniaturization - methods
Needles
Stress, Mechanical
Vibration
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Summary:The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to insert microneedles into excized animal tissue was measured with a load cell. Results showed a greater than 70% reduction in microneedle insertion force by using vibratory actuation. The application of vibratory actuation provides a promising method to precisely control the microneedle insertion forces to overcome microneedle structural material limitations, minimize insertion pain, and enhance the efficiency of drug delivery.
ISSN:1387-2176
1572-8781
DOI:10.1023/B:BMMD.0000042046.07678.2e