Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia

In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating h...

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Bibliographic Details
Published in:Blood cells, molecules, & diseases molecules, & diseases, 2009-03, Vol.42 (2), p.121-125
Main Authors: Pombo de Oliveira, Maria S., Koifman, Sergio, Vasconcelos, Gisele M., Emerenciano, Mariana, de Oliveira Novaes, Cristiane
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Biomarkers, Tumor
Brazil - epidemiology
Child
Child, Preschool
Childhood leukemia
Disease Susceptibility
Down Syndrome - epidemiology
Down Syndrome - genetics
Environmental risk factors
Female
Forecasting
GATA1 Transcription Factor - genetics
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Histone-Lysine N-Methyltransferase
Hospitals - statistics & numerical data
Humans
Immunophenotyping
Incidence
Infant
Information Services - organization & administration
Leukemia - epidemiology
Leukemia - genetics
Leukemia - immunology
Male
Myeloid-Lymphoid Leukemia Protein - genetics
Registries - statistics & numerical data
Risk
Transplacental exposure
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Description
Summary:In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological reviews including immunophenotyping and molecular characterization of childhood leukemias. The unique characteristics of the Brazilian population combined with a large clinical and epidemiologic framework for patient ascertainment has enabled large-scale epidemiological studies on childhood leukemia in Brazil.
ISSN:1079-9796
1096-0961
DOI:10.1016/j.bcmd.2008.10.012