Neurogenesis in the subventricular zone following transcranial magnetic field stimulation and nigrostriatal lesions

Neurogenesis continues at least in two regions of the mammalian adult brain, the subventricular zone (SVZ) and the subgranular zone in hippocampal dentate gyrus. Neurogenesis in these regions is subjected to physiological regulation and can be modified by pharmacological and pathological events. Her...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroscience research 2004-10, Vol.78 (1), p.16-28
Main Authors: Arias-Carrión, O., Verdugo-Díaz, L., Feria-Velasco, A., Millán-Aldaco, D., Gutiérrez, A.A., Hernández-Cruz, A., Drucker-Colín, R.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
brain insults
Cell Differentiation - physiology
Cell Transplantation
Cerebral Ventricles - cytology
Cerebral Ventricles - physiology
Chromaffin Cells - transplantation
Corpus Striatum - cytology
Corpus Striatum - physiology
Corpus Striatum - transplantation
Electric Stimulation - methods
Electromagnetic Fields
grafts
magnetic fields
Male
Neurons - cytology
Neurons - physiology
Rats
Rats, Wistar
Substantia Nigra - cytology
Substantia Nigra - physiology
Substantia Nigra - transplantation
substantia nigra lesions
subventricular zone
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurogenesis continues at least in two regions of the mammalian adult brain, the subventricular zone (SVZ) and the subgranular zone in hippocampal dentate gyrus. Neurogenesis in these regions is subjected to physiological regulation and can be modified by pharmacological and pathological events. Here we report the induction of neurogenesis in the SVZ and the differentiation after nigrostriatal pathway lesion along with transcranial magnetic field stimulation (TMFS) in adult rats. Significant numbers of proliferating cells demonstrated by bromodeoxyuridine‐positive reaction colocalized with the neuronal marker NeuN were detected bilaterally in the SVZ, and several of these cells also expressed tyrosine hydroxylase. Transplanted chromaffin cells into lesioned animals also induced bilateral appearance of subependymal cells. These results show for the first time that unilateral lesion, transplant, and/or TMFS induce neurogenesis in the SVZ of rats and also that TMFS prevents the motor alterations induced by the lesion. © 2004 Wiley‐Liss, Inc.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.20235