Independent origins of subgroup Bl + B2 and subgroup B3 metallo-beta-lactamases

The metallo-beta-lactamases constitute Class B in the Ambler classification of beta-lactamases and are divided into three subclasses: Bl, B2, and B3. Bayesian phylogenies of the Subclass B1 + B2 and Subclass B3 metallo-beta-lactamases and their homologs show that the beta-lactam-hydrolyzing function...

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Bibliographic Details
Published in:Journal of molecular evolution 2004-07, Vol.59 (1), p.133-141
Main Authors: Hall, Barry G, Salipante, Stephen J, Barlow, Miriam
Format: Article
Language:English
Subjects:
Archaea - genetics
Bacteria - genetics
Bayes Theorem
beta-Lactamases - genetics
Cloning, Molecular
Computational Biology
Databases, Nucleic Acid
DNA Primers
Drug Resistance, Bacterial - genetics
Eubacteria
Evolution, Molecular
Gene Expression
Models, Genetic
Phylogeny
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Summary:The metallo-beta-lactamases constitute Class B in the Ambler classification of beta-lactamases and are divided into three subclasses: Bl, B2, and B3. Bayesian phylogenies of the Subclass B1 + B2 and Subclass B3 metallo-beta-lactamases and their homologs show that the beta-lactam-hydrolyzing function evolved independently within each group. In Subclass B1+B2 that function evolved about 1 billion years ago, and in Subclass B3 it evolved before the divergence of the Gram-positive and Gram-negative eubacteria, about 2 billion years ago. These results lend additional support to the proposal that the metallo-beta-lactamases should be divided into two distinct classes.
ISSN:0022-2844
1432-1432
DOI:10.1007/s00239-003-2572-9