Ultrasound assessment of endothelial function in Chilean children and adults

Endothelial dysfunction is an important pathogenetic mechanism in the development of atherosclerosis. To evaluate endothelial function in Chilean children and adult subjects and to provide normal values of flow mediated dilatation (FMD) in the Chilean population. Flow mediated dilation of the brachi...

Full description

Saved in:
Bibliographic Details
Published in:Revista medíca de Chile 2004-04, Vol.132 (4), p.437-444
Main Authors: Germain, Alfredo M, Irribarra, Verónica, Valdés, Gloria, Romanik, Mary Carmen, Leighton, Federico, Mardones, Francisco, Cuevas, Ada
Format: Article
Language:por ; spa
Subjects:
Adolescent
Adult
Aged
Blood Flow Velocity - physiology
Brachial Artery - diagnostic imaging
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Child
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - physiology
Female
Humans
Male
Middle Aged
Pregnancy
Sex Factors
Ultrasonography
Vasodilation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endothelial dysfunction is an important pathogenetic mechanism in the development of atherosclerosis. To evaluate endothelial function in Chilean children and adult subjects and to provide normal values of flow mediated dilatation (FMD) in the Chilean population. Flow mediated dilation of the brachial artery was measured by high resolution ultrasonography in healthy children (n=32) and adults (n=69) of both gender, in a group of 8 healthy women during 4 periods of pregnancy and late postpartum, and in 22 men and women with a history of stroke or coronary heart disease. FMD in boys and girls was 9.9 +/- 3.6 and 10.0 +/- 4.2% respectively (NS). The figures for young women and young men were 11.3 +/- 3.8 and 8.6 +/- 3.9, respectively (p=0.02); for postmenopausal women and older men, 5.5 +/- 6.6 and 7.6 +/- 6.7 respectively (NS). During normal pregnancy and postpartum there were no significant changes in FMD. Patients with cardiovascular disease had a FMD of 0.3 +/- 5.2%, (p
ISSN:0034-9887