NMR Wool Tube: a novel method for NMR solution analysis of derivatized glass surfaces

Glass wool was placed within an NMR tube as a solid support for the covalent attachment of a molecule to allow for a simple one-dimensional 1H FT NMR solution analysis. This novel procedure avoids the use of expensive sample tubes or platforms, as required for magic angle or fast spinning, exotic pu...

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Bibliographic Details
Published in:Journal of Chromatography A 2004-08, Vol.1046 (1-2), p.277-287
Main Author: CHOLEWA, Olivia Maria
Format: Article
Language:English
Subjects:
Analysis
Analytical biochemistry: general aspects, technics, instrumentation
Analytical chemistry
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General pharmacology
Glass
Magnetic Resonance Spectroscopy - methods
Medical sciences
Pharmacology. Drug treatments
Surface Properties
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Summary:Glass wool was placed within an NMR tube as a solid support for the covalent attachment of a molecule to allow for a simple one-dimensional 1H FT NMR solution analysis. This novel procedure avoids the use of expensive sample tubes or platforms, as required for magic angle or fast spinning, exotic pulse sequences, isotopic labeling or the use of a large number of scans to provide the ability to analyze the structure, mobility, ligand binding, and solvent interactions of the surface bound molecule.
ISSN:0021-9673
DOI:10.1016/S0021-9673(04)01022-2