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Iridoids from the aerial parts of Verbena littoralis (Verbenaceae)
Iridoids ( 1) and ( 2), were isolated from the aerial parts of Verbena littoralis. Both showed moderate in vitro activity against gram positive and negative bacteria, and peristaltic action in the mouse. Free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxi...
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| Published in: | Phytochemistry (Oxford) 2004-08, Vol.65 (16), p.2369-2372 |
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| cites | cdi_FETCH-LOGICAL-c547t-46953b4449060b0184563f8be7117c537f6e2699266956ce5e05ab64afaa95083 |
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| container_title | Phytochemistry (Oxford) |
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| creator | Castro-Gamboa, Ian Castro, Oscar |
| description | Iridoids (
1) and (
2), were isolated from the aerial parts of
Verbena littoralis. Both showed moderate in vitro activity against gram positive and negative bacteria, and peristaltic action in the mouse. Free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity as evidenced by redox properties measured on ElCD-HPLCl was observed.
The iridoids, 6
S-hydroxy-8
S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one and 6
S,9
S-dihydroxy-8S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one, were isolated from the aerial parts of
Verbena littoralis. Their structures and stereochemistry were elucidated by means of NMR spectral data analysis. Both compounds showed moderate in vitro activity against gram positive and negative bacteria as well as moderate in vivo intestinal peristaltic action in mouse. The iridoids also showed moderate free radical scavenging activity against l,l-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity, the latter being evidenced by redox properties measured using E1CD-HPLC. |
| doi_str_mv | 10.1016/j.phytochem.2004.07.008 |
| format | article |
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1) and (
2), were isolated from the aerial parts of
Verbena littoralis. Both showed moderate in vitro activity against gram positive and negative bacteria, and peristaltic action in the mouse. Free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity as evidenced by redox properties measured on ElCD-HPLCl was observed.
The iridoids, 6
S-hydroxy-8
S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one and 6
S,9
S-dihydroxy-8S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one, were isolated from the aerial parts of
Verbena littoralis. Their structures and stereochemistry were elucidated by means of NMR spectral data analysis. Both compounds showed moderate in vitro activity against gram positive and negative bacteria as well as moderate in vivo intestinal peristaltic action in mouse. The iridoids also showed moderate free radical scavenging activity against l,l-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity, the latter being evidenced by redox properties measured using E1CD-HPLC.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2004.07.008</identifier><identifier>PMID: 15381009</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Animals ; Antibacterial activity ; antibacterial properties ; Antioxidant ; antioxidant activity ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Bacillus subtilis ; Biological and medical sciences ; Chemical constitution ; chemical structure ; chemotaxonomy ; Chromatography, High Pressure Liquid ; free radical scavenging activity ; Fundamental and applied biological sciences. Psychology ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; intestinal peristaltic reflex ; intestines ; Intestines - metabolism ; Iridoids ; Iridoids - chemistry ; Iridoids - isolation & purification ; Iridoids - pharmacology ; Klebsiella pneumoniae ; medicinal plants ; Mice ; Oxidation-Reduction ; Peristalsis - drug effects ; phytochemicals ; Plant cytology, morphology, systematics, chorology and evolution ; plant extracts ; Plant physiology and development ; rats ; spectral analysis ; Spermatophyta ; stereochemistry ; Stereoisomerism ; Systematics (diagnosis, chromosome numbers) ; Verbena ; Verbena littoralis ; Verbenaceae ; Verbenaceae - chemistry</subject><ispartof>Phytochemistry (Oxford), 2004-08, Vol.65 (16), p.2369-2372</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-46953b4449060b0184563f8be7117c537f6e2699266956ce5e05ab64afaa95083</citedby><cites>FETCH-LOGICAL-c547t-46953b4449060b0184563f8be7117c537f6e2699266956ce5e05ab64afaa95083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16147989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15381009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro-Gamboa, Ian</creatorcontrib><creatorcontrib>Castro, Oscar</creatorcontrib><title>Iridoids from the aerial parts of Verbena littoralis (Verbenaceae)</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Iridoids (
1) and (
2), were isolated from the aerial parts of
Verbena littoralis. Both showed moderate in vitro activity against gram positive and negative bacteria, and peristaltic action in the mouse. Free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity as evidenced by redox properties measured on ElCD-HPLCl was observed.
The iridoids, 6
S-hydroxy-8
S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one and 6
S,9
S-dihydroxy-8S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one, were isolated from the aerial parts of
Verbena littoralis. Their structures and stereochemistry were elucidated by means of NMR spectral data analysis. Both compounds showed moderate in vitro activity against gram positive and negative bacteria as well as moderate in vivo intestinal peristaltic action in mouse. The iridoids also showed moderate free radical scavenging activity against l,l-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity, the latter being evidenced by redox properties measured using E1CD-HPLC.</description><subject>Animals</subject><subject>Antibacterial activity</subject><subject>antibacterial properties</subject><subject>Antioxidant</subject><subject>antioxidant activity</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Bacillus subtilis</subject><subject>Biological and medical sciences</subject><subject>Chemical constitution</subject><subject>chemical structure</subject><subject>chemotaxonomy</subject><subject>Chromatography, High Pressure Liquid</subject><subject>free radical scavenging activity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>intestinal peristaltic reflex</subject><subject>intestines</subject><subject>Intestines - metabolism</subject><subject>Iridoids</subject><subject>Iridoids - chemistry</subject><subject>Iridoids - isolation & purification</subject><subject>Iridoids - pharmacology</subject><subject>Klebsiella pneumoniae</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Oxidation-Reduction</subject><subject>Peristalsis - drug effects</subject><subject>phytochemicals</subject><subject>Plant cytology, morphology, systematics, chorology and evolution</subject><subject>plant extracts</subject><subject>Plant physiology and development</subject><subject>rats</subject><subject>spectral analysis</subject><subject>Spermatophyta</subject><subject>stereochemistry</subject><subject>Stereoisomerism</subject><subject>Systematics (diagnosis, chromosome numbers)</subject><subject>Verbena</subject><subject>Verbena littoralis</subject><subject>Verbenaceae</subject><subject>Verbenaceae - chemistry</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqF0ctu1DAUBmALgei08Ao0G1BZJBzf42WpuFSqxALK1nI8x4xHyXiwM0h9ezxMRJddHcn6zkW_Cbmk0FGg6sO2228e5uQ3OHUMQHSgO4D-GVnRXvOWa4DnZAXAaWsEY2fkvJQtAEip1EtyRiXvKYBZkY-3Oa5TXJcm5DQ18wYbhzm6sdm7PJcmheYn5gF3rhnjPKfsxliaq-XNo8P3r8iL4MaCr5d6Qe4_f_px87W9-_bl9ub6rvVS6LkVykg-CCEMKBiA9kIqHvoBNaXaS66DQqaMYapC5VEiSDco4YJzRkLPL8i709x9Tr8PWGY7xeJxHN0O06HY2geMSfkkpEYrw3tRoT5Bn1MpGYPd5zi5_GAp2GPOdmv_52yPOVvQFv7d8mZZcRgmXD_2LcFW8HYBrng3hux2PpZHp6jQpj-6y5MLLln3K1dz_50B5XWIVExCFdcngTXbPxGzLT7izuM6ZvSzrb_35Ll_AWadpuY</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Castro-Gamboa, Ian</creator><creator>Castro, Oscar</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>Iridoids from the aerial parts of Verbena littoralis (Verbenaceae)</title><author>Castro-Gamboa, Ian ; Castro, Oscar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-46953b4449060b0184563f8be7117c537f6e2699266956ce5e05ab64afaa95083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antibacterial activity</topic><topic>antibacterial properties</topic><topic>Antioxidant</topic><topic>antioxidant activity</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Bacillus subtilis</topic><topic>Biological and medical sciences</topic><topic>Chemical constitution</topic><topic>chemical structure</topic><topic>chemotaxonomy</topic><topic>Chromatography, High Pressure Liquid</topic><topic>free radical scavenging activity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>intestinal peristaltic reflex</topic><topic>intestines</topic><topic>Intestines - metabolism</topic><topic>Iridoids</topic><topic>Iridoids - chemistry</topic><topic>Iridoids - isolation & purification</topic><topic>Iridoids - pharmacology</topic><topic>Klebsiella pneumoniae</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Oxidation-Reduction</topic><topic>Peristalsis - drug effects</topic><topic>phytochemicals</topic><topic>Plant cytology, morphology, systematics, chorology and evolution</topic><topic>plant extracts</topic><topic>Plant physiology and development</topic><topic>rats</topic><topic>spectral analysis</topic><topic>Spermatophyta</topic><topic>stereochemistry</topic><topic>Stereoisomerism</topic><topic>Systematics (diagnosis, chromosome numbers)</topic><topic>Verbena</topic><topic>Verbena littoralis</topic><topic>Verbenaceae</topic><topic>Verbenaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro-Gamboa, Ian</creatorcontrib><creatorcontrib>Castro, Oscar</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro-Gamboa, Ian</au><au>Castro, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iridoids from the aerial parts of Verbena littoralis (Verbenaceae)</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>65</volume><issue>16</issue><spage>2369</spage><epage>2372</epage><pages>2369-2372</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Iridoids (
1) and (
2), were isolated from the aerial parts of
Verbena littoralis. Both showed moderate in vitro activity against gram positive and negative bacteria, and peristaltic action in the mouse. Free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity as evidenced by redox properties measured on ElCD-HPLCl was observed.
The iridoids, 6
S-hydroxy-8
S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one and 6
S,9
S-dihydroxy-8S-methyl-4-methylene-hexahydro-cyclopenta[
c]pyran-3-one, were isolated from the aerial parts of
Verbena littoralis. Their structures and stereochemistry were elucidated by means of NMR spectral data analysis. Both compounds showed moderate in vitro activity against gram positive and negative bacteria as well as moderate in vivo intestinal peristaltic action in mouse. The iridoids also showed moderate free radical scavenging activity against l,l-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity, the latter being evidenced by redox properties measured using E1CD-HPLC.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>15381009</pmid><doi>10.1016/j.phytochem.2004.07.008</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2004-08, Vol.65 (16), p.2369-2372 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66902255 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Antibacterial activity antibacterial properties Antioxidant antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Bacillus subtilis Biological and medical sciences Chemical constitution chemical structure chemotaxonomy Chromatography, High Pressure Liquid free radical scavenging activity Fundamental and applied biological sciences. Psychology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects intestinal peristaltic reflex intestines Intestines - metabolism Iridoids Iridoids - chemistry Iridoids - isolation & purification Iridoids - pharmacology Klebsiella pneumoniae medicinal plants Mice Oxidation-Reduction Peristalsis - drug effects phytochemicals Plant cytology, morphology, systematics, chorology and evolution plant extracts Plant physiology and development rats spectral analysis Spermatophyta stereochemistry Stereoisomerism Systematics (diagnosis, chromosome numbers) Verbena Verbena littoralis Verbenaceae Verbenaceae - chemistry |
| title | Iridoids from the aerial parts of Verbena littoralis (Verbenaceae) |
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